Mahdi Deljou; Mohammad Reza Aslani; Mehrdad Mohri; Ahmad Reza Movassaghi; Mohammad Heidarpour
Volume 5, Issue 3 , July 2014, , Pages 161-167
Abstract
Toxic effects of monensin, a polyether antibiotic mainly used as a coccidiostat, have been described in a wide range of animals. The present study was performed to investigate the toxic effects of monensin in goats. Seven adult goats were administered sodium monensin, 13.5 mg kg-1, daily for five consecutive ...
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Toxic effects of monensin, a polyether antibiotic mainly used as a coccidiostat, have been described in a wide range of animals. The present study was performed to investigate the toxic effects of monensin in goats. Seven adult goats were administered sodium monensin, 13.5 mg kg-1, daily for five consecutive days via gastric gavage. Monensin toxicity was evaluated by clinical signs, serum biochemistry and pathology. Monensin exposure caused diarrhea, tachycardia and reduction in ruminal movements and body temperature. Significant increase of creatine kinase, lactate dehydrogenase, aspartate aminotransferase, total bilirubin, blood urea nitrogen, creatinine and erythrocyte superoxide dismutase were observed in monensin exposed goats. Reduction of erythrocyte glutathione peroxidase and elevation of serum malondialdehyde and troponin I were inconsistent. In necropsy, there were effusions in body cavities, vacuolar degeneration and coagulative necrosis in cardiac and skeletal muscles and renal tubular necrosis. These findings suggested that monensin intoxication in goats leads to cardiac, skeletal and renal damage and a wide range of biochemical abnormalities. Oxidative stress may be involved in the pathogenesis of monensin poisoning.
Mohammad Reza Aslani; Mehrdad Mohri; Ahmad Reza Movassaghi
Volume 4, Issue 1 , March 2013, , Pages 59-62
Abstract
Foot and mouth disease (FMD) is a highly contagious viral disease of cloven-hooved livestock and wildlife results to relatively high mortality in young animals. Despite the numerous reports of FMD-related death in neonates, there is little data available on various aspects of FMD in lambs. This report ...
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Foot and mouth disease (FMD) is a highly contagious viral disease of cloven-hooved livestock and wildlife results to relatively high mortality in young animals. Despite the numerous reports of FMD-related death in neonates, there is little data available on various aspects of FMD in lambs. This report describes myocarditis associated with FMD in five, one week to three months old lambs. The lambs were depressed and afebrile and two of lambs showed foamy salivation associated with shallow ulcers in oral cavity. Electrocardiography (ECG) revealed sinus tachycardia, multifocal ventricular premature beats and ventricular fibrillation. Serum biochemistry showed high levels of troponin I concentration and CK and AST activity. In Pathology, there were multiple pale areas in the subepicardial and subendocardial muscles and; widespread degeneration and coagulative necrosis of myocardium. The serum troponin I assay and ECG can be used for diagnosis of myocarditis and prognosis of affected lambs during FMD outbreak.