Alireza Arbati; Masoud Maham; Bahram Dalir-Naghadeh
Volume 12, Issue 3 , September 2021, , Pages 313-318
Abstract
Gastrointestinal motility disorders can occur as either increased or decreased movements. Studies have shown that herbal ingredients such as essential oils can modify the increase and decrease of gastrointestinal movements of ruminants. Cinnamaldehyde at room temperature is an oily yellow liquid which ...
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Gastrointestinal motility disorders can occur as either increased or decreased movements. Studies have shown that herbal ingredients such as essential oils can modify the increase and decrease of gastrointestinal movements of ruminants. Cinnamaldehyde at room temperature is an oily yellow liquid which is obtained from the steam distillation of the oil of cinnamon bark. It bears carminative activity and gastrointestinal, antimicrobial, and vasodilatory effects. This study examined the effects of cinnamaldehyde on the contraction of circular smooth muscles of abomasal fundus and the antrum, duodenum, and ileum of healthy cows using an in vitro approach. The results indicated that cinnamaldehyde had relaxant effects on the basal tonus and contractions caused by barium chloride (BaCl2) and carbachol (CCh) in these tissues dependent upon concentration and the origin of the smooth muscle. These effects were more prominent in the ileal smooth muscle preparations than in other tissues. This substance in the smooth muscle preparations of the abomasal fundus not only had no significant effect on the basal tonus, but also significantly increased the contractions caused by barium chloride at low concentrations. Study of the mechanism of action showed that, similar to verapamil, cinnamaldehyde applied its relaxation effect by blocking the calcium channels. The results showed that cinnamaldehyde possessed a spasmolytic effect mediated through blockage of the calcium channels, which may provide a pharmacological base to its medicinal use for diarrhea and spasms.
Amin Mamaghani; Masoud Maham; Bahram Dalir-Naghadeh
Volume 4, Issue 2 , June 2013, , Pages 91-97
Abstract
Reticulorumen hypomotility leads to the impaired physiologic functions of the digestive tract. Prokinetic action of ginger has been demonstrated in the laboratory animals and human. The aim of this study was to evaluate the effect of hydroalcoholic extract of ginger on contraction and motility of reticulum ...
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Reticulorumen hypomotility leads to the impaired physiologic functions of the digestive tract. Prokinetic action of ginger has been demonstrated in the laboratory animals and human. The aim of this study was to evaluate the effect of hydroalcoholic extract of ginger on contraction and motility of reticulum and rumen of ruminants. Collected samples of reticulum and rumen from eight sheep were investigated in vitro. The extract at the concentration of 0.1 and 1.0 mg L-1 had no effect on any preparations. Contraction of reticulum and rumen preparations was occurred at 10.0 and 100 mg L-1 concentrations (p < 0.05). Concentration of 1000 mg L-1 caused a relaxation in preparations contracted with 10.0 and 100 mg L-1. Likewise, the concentration of 1000 mg L-1 significantly (p < 0.05) inhibited ACh-induced contraction in both tissues. Six sheep were involved in electromyographic study. Administration of 40 mg kg-1 of the extract increased the overall frequency of contractions of the reticulum and rumen at the subsequent three days with the prominent increase at the second day (p < 0.05). Results of in vitro study indicated that hydroalcoholic extract of ginger contained spasmogenic and spasmolytic constituents. The results in vivo study represented evidences that the extract may have stimulant effect on reticulorumen motility in 40 mg kg-1 concentration.
