Mohammad Yasan Bangash; Mir Sepehr Pedram; Valiollah Mehrabi; Mohammad Mehdi Dehghan; Koorosh Mansoori; Sarang Soroori; Sanaz Banifazl; Forough Dadgar; Mohammad Reza Mokhber Dezfouli
Volume 13, Issue 2 , June 2022, , Pages 215-221
Abstract
The aim of this study was to introduce a new animal model of fecal incontinence (FI) by injecting abobotulinumtoxinA in the external anal sphincter (EAS) muscle of dogs which replaces models based on anal sphincter destructions that are invasive, mostly require surgical procedures, expensive, permanent, ...
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The aim of this study was to introduce a new animal model of fecal incontinence (FI) by injecting abobotulinumtoxinA in the external anal sphincter (EAS) muscle of dogs which replaces models based on anal sphincter destructions that are invasive, mostly require surgical procedures, expensive, permanent, and painful to the animals. 4 healthy mongrel dogs were used in this study. First, they were received NaCl 0.09% (as control) injections in EAS muscle and effects were assessed by means of Electromyography (EMG) and clinically evaluated by sphincter pinch test and presence of leakage of feces for 2 weeks. Then, they received abobotulinumtoxinA in EAS muscle and reevaluated for 6 weeks to see short-term and medium-term effects of abobotulinumtoxinA injection. Saline had no significant changes in results obtained from EMG, however, there were significant decreases in amplitudes of action potentials after receiving abobotulinumtoxinA in comparison with no injection or saline injection in EAS muscle. Pinch tests were normal after saline injection assessment period, however, then started to be negative, ranging from two days after abobotulinumtoxinA injection to seven days after receiving abobotulinumtoxinA. Animals also had significant presentations of fecal incontinence (leakage of feces and cage contamination with feces) from the 1st week after receiving abobotulinumtoxinA until the 6th week after receiving abobotulinumtoxinA. AbobotulinumtoxinA caused paralysis in the EAS and producd FI conditions in dogs. This animal model was an appropriate substitute to the various invasive, expensive and also complicated procedures with an easy, feasible, noninvasive and non-painful single-stage abobotulinumtoxinA injection.
Sarang Soroori; Soraya Saleh Gargari; Nima Sayyah; Mohammad Reza Esmaili Nejad
Volume 11, Issue 2 , June 2020, , Pages 165-170
Abstract
This study was performed to achieve abortion in a short time and with minimum side effects in a bitch, as an alternative method for termination of unwanted pregnancy. The experimentation was performed on 10 privately owned crossbred pregnant bitches, in their late second trimester of pregnancy, having ...
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This study was performed to achieve abortion in a short time and with minimum side effects in a bitch, as an alternative method for termination of unwanted pregnancy. The experimentation was performed on 10 privately owned crossbred pregnant bitches, in their late second trimester of pregnancy, having a variable number of fetuses (3 to 9). Fetal death was induced by transabdominal intracardiac injection of potassium chloride (KCl) into the fetal heart under ultrasonographic guidance. Pregnancy was terminated within 36 to 72 hr (51.60 ±16.04 hr) and none of the patients experienced any side effects or clinical complications. Data presented in this report provided evidence for the possible use of this technique to selectively reduce the number of canine fetuses without terminating the whole pregnancy. Ultrasound-guided induced fetal death is a safe procedure and a viable method for the induction of abortion in a short time and with no apparent side effects.
Diagnostic Imaging
Yasamin Vali; Sarang Soroori; Mohammad Molazem; Majid Masoudifard; Alireza Vajhi; Samaneh Keshavarz; Hesameddin Akbarein
Volume 10, Issue 1 , March 2019, , Pages 17-22
Abstract
Prostate gland can be structurally evaluated by computed tomography (CT) with taking advantages of tomographic feature and post-contrast parenchymal changes. The current examination initiated to determine association between computed tomographic and cytological results in evaluation of canine prostate. ...
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Prostate gland can be structurally evaluated by computed tomography (CT) with taking advantages of tomographic feature and post-contrast parenchymal changes. The current examination initiated to determine association between computed tomographic and cytological results in evaluation of canine prostate. Thirty mature male dogs were included and under gone by both CT and fine needle sampling of prostate. The cytology and CT examination results showed 18/30 (60.00%) and 15/30 (50.00%) normal prostate, 5/30 (16.66%) and 4/30 (13.33%) prostatitis and 7/30 (23.33%) and 11/30 (36.66%) benign prostatic hyperplasia, respectively. Moderate agreement has been found between cytology and final diagnosis based on pre-contrast CT images, however fair agreement was existed between cytological diagnosis and final CT interpretation according to post-contrast and both pre- and post- contrast CT series. Additionally, the internal iliac lymph node length showed statistically significant difference in prostatitis compared to normal and benign hyperplastic prostates in this study. In conclusion, the fair and moderate associations between cytology and final diagnosis based on CT images should be considered and they can be used in further investigations and clinical examinations. Also, using internal iliac lymph node length to differentiate prostatitis with normal and benign hyperplastic prostates can be used efficiently in diagnosis to choose the best method of management and have a proper follow up and prognosis.
