Volume 15 (2024)
Volume 14 (2023)
Volume 13 (2022)
Volume 12 (2021)
Volume 11 (2020)
Volume 10 (2019)
Volume 9 (2018)
Volume 8 (2017)
Volume 7 (2016)
Volume 6 (2015)
Volume 5 (2014)
Volume 4 (2013)
Volume 3 (2012)
Volume 2 (2011)
Volume 1 (2010)
Exploring the main effects of Phoenix dactylifera on destructive changes caused by cyclophosphamide in male reproductive system in mice

Narges Delgarm; Majid Morovati Sharifabad; Elham Salehi; Mohammad Afkhami-Ardakani; Mohammad Saeed Heydarnejad

Volume 13, Issue 2 , June 2022, , Pages 249-255

Abstract
  Cyclophosphamide leaves an undesirable effect on testes. This study was conducted to explore the effects of the Phoenix dactylifera (DP) on testes following the cyclophosphamide treatment. Thirty-six male mice were divided into six groups, one control, one cyclophosphamide, two groups of cyclophosphamide ...  Read More

Possible protective effects of crocin on destructive side effects of cyclo-phosphamide in mice ovarian tissue: Evaluation of histomorphometrical and biochemical changes

Fahimeh Khanmohammadi; Rasoul Shahrooz; Abbas Ahmadi; Mazdak Razi

Volume 12, Issue 2 , June 2021, , Pages 217-222

Abstract
  One of the side effects of cyclophosphamide (CP) is low fertility. In this study, we investigated the protective role of crocin (Cr) against CP chemotherapy-induced changes in ovarian tissue. In the current study, we treated 15 female mice aged 6-8 weeks old for 21 days. The mice were distributed into ...  Read More

Protective effect of ethyl pyruvate on testicular histology and fertilization potential in cyclophosphamide treated mice

Zahra Bakhtiary; Rasoul Shahrooz; Abbas Ahmadi; Farhad Soltanalinejad

Volume 11, Issue 1 , March 2020, , Pages 7-13

Abstract
  In the present study, we aimed to address the use of ethyl pyruvate (EP) against the harmful effects of cyclophosphamide (CP) treatment. Thirty-nine adult male mice were divided into three groups including control group received normal saline [0.20 mL per day; intraperitoneally (IP)], CP group received ...  Read More

Clinical Pathology
Comparative study of the protective effects of chicken embryo amniotic fluid, vitamin C and coenzyme Q10 on cyclophosphamide-induced oxidative stress in mice ovaries

Alireza Kabirian; Rooz Ali Batavani; Siamak Asri-Rezaei; Ali Soleimanzadeh

Volume 9, Issue 3 , September 2018, , Pages 217-224

Abstract
  Cyclophosphamide is a chemotherapy drug for the treatment of cancer. Chicken embryo amniotic fluid, vitamin C and coenzyme Q10 have anti-oxidant properties. Total of 70 adult female mice were selected and divided into seven groups. The first group that received 2 ml kg-1 of inactivated amniotic fluid ...  Read More

Histology
Antioxidant effects of Spirulina platensis (Arthrospira platensis) on ‎cyclophosphamide-induced testicular injury in rats

Mohammad Afkhami-Ardakani; Shapour Hasanzadeh; Rasoul Shahrooz; Norouz Delirezh; Hassan Malekinejad

Volume 9, Issue 1 , March 2018, , Pages 35-41

Abstract
  Cyclophosphamide (CP) is known to reduce fertility. The protective effects of Spirulina plantesis (SP) against CP-induced testicular toxicity were investigated. Male Wistar rats were categorized into eight groups (n = 7). Four groups of rats were administered CP at a dose of 5 mg in 5 mL distilled water ...  Read More

Embryology
Protective effect of quercetin on skeletal and neural tube teratogenicity induced by cyclophosphamide in rat fetuses

Mahmood Khaksary Mahabady; Mohammad Reza Gholami; Hossein Najafzadeh Varzi; Abolfazl Zende del; Mona Doostizadeh

Volume 7, Issue 2 , June 2016, , Pages 133-138

Abstract
  Cyclophosphamide (CP) is a drug commonly used to treat neoplastic disease and some autoimmune diseases. It is also a well-known and well-studied teratogen causing a variety of birth defects in fetuses of pregnant women treated with the drug. There are many reports that show the adverse effects of CP ...  Read More

Evaluation of antioxidant effects of crocin on sperm quality in cyclophosphamide treated adult mice

Zahra Bakhtiary; Rasoul Shahrooz; Abbas Ahmadi; Leila Zarei

Volume 5, Issue 3 , July 2014, , Pages 213-218

Abstract
  Cyclophosphamide (CP) is one of the anti-neoplastic drugs. Despite its numerous clinical applications, it has devastating effects on the testicles and declines the sperm quality in treated patients. This study was aimed to investigate the protective effect of crocin in improving the toxicity induced ...  Read More

Chemoprotective effect of Crataegus monogyna aqueous extract against cyclophosphamide-induced reproductive toxicity

Ali Shalizar Jalali; Shapour Hassanzadeh; Hassan Malekinejad

Volume 2, Issue 4 , December 2011, , Pages 266-273

Abstract
  Cyclophosphamide (CP) is extensively used as an antineoplastic agent for treatment of various cancers, as well as an immunosuppressive agent. However, despite its wide spectrum of clinical uses, CP is known to cause several adverse effects including reproductive toxicity in humans and experimental animals. ...  Read More