TY - JOUR ID - 18999 TI - The effects of pomegranate extract on normal adult rat kidney: A stereological study JO - Veterinary Research Forum JA - VRF LA - en SN - 2008-8140 AU - Mansouri, Esrafil AU - Basgen, John AU - Saremy, Sadegh AD - Department of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran AD - Life Sciences Institute, Charles R. Drew University of Medicine and Science, Los Angeles, USA Y1 - 2016 PY - 2016 VL - 7 IS - 1 SP - 1 EP - 6 KW - Kidney KW - Pomegranate KW - Rat KW - Stereology DO - N2 - Pomegranate (Punica granatum L.) has been used widely in the traditional medicine of various civilizations for more than 5000 years. The pomegranate tree has several parts; each part has useful medicinal effects. Previous studies have demonstrated the antibacterial, antioxidant, and anti-inflammatory properties of pomegranate. The aim of the present study was to determine whether administration of pomegranate extract could result in morphometric changes in the kidneys of rats. Eighteen male rats (180-200 g) were divided into three groups that received either: G1, distilled water; G2, 250 mg kg-1 pomegranate extract; and G3, 500 mg kg-1 pomegranate extract via oral gavages daily for eight weeks. At the end of eight weeks, the rats were euthanized and their kidneys were removed and processed for morphometric analyses. In rats received pomegranate extract, the kidney weight, kidney weight/body weight ratio, cortex volume and glomerular volume were increased (p < 0.05), while, medulla volume and the number of glomeruli per kidney did not change. No pathological lesions were observed in the kidney. Therefore, pomegranate hydro-alcoholic extract at doses of 250 and 500 (mg kg-1) increased the volume of some parts of the kidney; however, it did not cause any pathological changes in the kidney. UR - https://vrf.iranjournals.ir/article_18999.html L1 - https://vrf.iranjournals.ir/article_18999_b2a80f714d3b2c936efe01fa3bdb343b.pdf ER -