Occurrence of myxoma in a bearded dragon (Pogona vitticeps): Surgical and histopathological studies

Document Type : Clinical Report


1 Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

2 Department of Radiology and Surgery, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

3 DVM Student, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran


Myxoma is a benign mesenchymal tumor of skin and soft connective tissues considered to be of fibroblastic origin. A female bearded dragon (Pogona vitticeps) with a raised mass on the left side of the body was referred to the Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.The mass had become evident and grew more extensive within the previous 11-month period. The dragon was anesthetized with 5.00% isoflurane, and the mass was removed surgically. Tissue samples of the mass were fixed in 10.00% neutral buffered formalin, sectioned and stained with Hematoxylin and Eosin  (H&E), Alcian blue (pH: 2.50), and periodic acid Schiff (PAS) staining techniques. The patient was administered meloxicam, lincomycin, and marbofloxacin. Histopathologically, the capsulated mass was composed of myxoid structure. Stellate-to-reticular cells distributed in a mucinous stroma containing few tiny blood vessels were seen. Myxoid cells displayed a PAS-positive cytoplasm. The myxomatous matrix was alcianophilic at the pH of 2.50. To our knowledge, this is the first report of surgery, treatment, and histopathological study of myxoma in a bearded dragon (P. vitticeps). The sutures were also removed 12 days after the operation. No new growth of the mass was observed three months following the surgical procedures.


  1. Hendrick MJ. Mesenchymal tumors of the skin and soft tissues. In: Meuten DJ (Ed) Tumors in domestic animals. 5th ed. Ames, USA; John Wiley & Sons Inc. 2017; 142-175.
  2. Campbell MD, Gelberg HB. Endocardial ossifying myxoma of the right atrium in a cat. Vet Pathol 2000; 37(5): 460-462.
  3. Berrocal A, Millan Y, Ordas J, et al. A joint myxoma in a dog. J Comp Pathol 2001; 124(2-3): 223-226.
  4. Yeruham I, Perl S. Melanocytoma and myxoma-tumors of the limbs in cattle. Berl Munch Tierarztl Wochenschr 2002; 115(11-12): 425-427.
  5. Totsugawa T, Kuinose M, Nishigawa K, et al. Intraseptal biatrial myxoma excised via the superior septal approach. Gen Thorac Cardiovasc Surg 2008; 56(6): 298-301.
  6. Barten SD, Frye FL. Leiomyosarcoma and myxoma in a Texas indigo snake. J Am Vet Med Assoc 1981; 179(11): 1292-1295.
  7. Mikaelian I, Levine BS, Smith SG, et al. Malignant peri-pheral nerve sheath tumor in a bearded dragon, Pogona vitticeps. J Herpetol Med Surg 2001; 11(1): 9-12.
  8. Hannon DE, Garner MM, Reavill DR. Squamous cell carcinomas in inland bearded dragons (Pogona vitticeps). J Herpetol Med Surg 2011; 21(4): 101-106.
  9. Heckers KO, Aupperle H, Schmidt V, et al. Melanophoromas and iridophoromas in reptiles. J Comp Pathol 2012; 146(2-3): 258-268.
  10. Darrow BG, JohnstoneMclean NS, Russman SE, et al. Periorbital adenocarcinoma in a bearded dragon (Pogona vitticeps). Vet Ophthalmol 2013; 16(Suppl 1): 177-182.
  11. Gardhouse S, Eshar D, Lee-Chow B, et al. Diagnosis and treatment of a periocular myxosarcoma in a bearded dragon (Pogonavitticeps). Can Vet J 2014; 55(7): 663-666.
  12. Hernandez-Divers SM, Garner MM. Neoplasia of reptiles with an emphasis on lizards. Vet Clin North Am Exot Anim Pract 2003; 6(1): 251-273.
  13. Dietz J, Heckers KO, Aupperle H, et al. Cutaneous and subcutaneous soft tissue tumours in snakes: A retrospective study of 33 cases. J Comp Pathol 2016; 155(1): 76-87.
  14. Henríquez A, Loyola M, Leichtle J. Subcutaneous myxomas in kelp gulls (Larus dominicanus) in Chile. J Wildl Dis 2019; 55(1): 270-272.
  15. Vail D, Thamm D, Liptak J. Withrow and MacEwen’s small animal clinical oncology. 6th ed. St. Louis, USA: Saunders 2019; 356-380.
Volume 12, Issue 1
March 2021
Pages 129-131
  • Receive Date: 01 January 2020
  • Revise Date: 06 February 2020
  • Accept Date: 28 March 2020
  • First Publish Date: 28 December 2020