Effect of prostaglandin F2α and GnRH administration at the time of artificial insemination on reproductive performance of dairy cows

Mohammadi, Abolfazl; Seifi, Hesam; Farzaneh, Nima

doi:10.30466/vrf.2018.87502.2136

Document Type : Original Article

Authors

Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

https://doi.org/10.30466/vrf.2018.87502.2136

Abstract

The present study aimed to determine the effect of administrating prostaglandin F2α (PGF2α) and GnRH at the time of artificial insemination (AI) on the pregnancy per artificial insemination (P/AI) and the pregnancy survival rate of dairy cows. A number of 830 lactating Holstein cows were randomly divided into four groups. Cows in group 1 (n=200) treated with 150 µg d-cloprostenol. In group 2 (n=212), cows received 10 µg buserelin acetate, and group 3 (n=205) was treated with both 150 µg d-cloprostenol and 10 µg buserelin acetate. In addition, 213 cows were assigned as control group which received normal saline as placebo (group 4). To measure progesterone, milk samples were collected at the insemination day and five days later. Pregnancy diagnosis was performed 28 and 60 days after the insemination, and the size and number of corpus luteum (CL) and twin pregnancies were recorded. Hormone therapies had no effect on the P/AI, pregnancy survival rate, and the size and number of CL. The P/AI ratio in groups 1, 2, 3 and 4 were 38.50%, 42.92%, 41.46% and 40.84%, and the pregnancy survival rates in groups 1, 2, 3 and 4 were 84.42%, 86.81%, 88.23% and 83.91%, respectively. The probability of a twin pregnancy was significantly higher in group 1 (15.58%) than other groups. There was no significant difference between groups in terms of the offspring gender. In conclusion, the administration of d-cloprostenol or buserelin acetate at the time of AI had no effect on P/AI and pregnancy survival rate in dairy cattle under no heat stress condition, while the administration of d-cloprostenol increased the probability of twin pregnancies.

Keywords

Main Subjects

Theriogenology

References

1. Lucy MC. Reproductive loss in high-producing dairy cattle: Where will it end? J Dairy Sci 2001; 84 (6): 1277-1293.
2. Walsh SW, Williams EJ, Evans AC. A review of the causes of poor fertility in high milk producing dairy cows. Anim Reprod Sci 2011; 123 (3-4): 127-138.
3. Prinzen R, Allgayer F, Bartz U, et al. Effects of prostaglandin F2α on the conception result of heifers and cows. Tierärtzliche Umschau 1991; 46: 27-35.
4. López-Gatius F, Yaniz JL, Santolaria P, et al. Reproductive performance of lactating dairy cows treated with cloprostenol at the time of insemination. Theriogenology 2004; 62 (3-4): 677-689.
5. Ambrose DJ, Gobikrushanth M, Zuidhof S, et al. Low-dose natural prostaglandin F2α (dinoprost) at timed insemination improves conception rate in dairy cattle. Theriogenology 2015; 83 (4): 529-534.
6. Pfeifer LF, Siqueira LG, Mapletoft RJ, et al. Effects of exogenous progesterone and cloprostenol on ovarian follicular development and first ovulation in prepubertal heifers. Theriogenology 2009; 72 (8): 1054-1064.
7. Leonardi CE, Pfeifer LF, Rubin MI, et al. Prostaglandin F2α promotes ovulation in prepubertal heifers. Theriogenology 2012; 78 (7): 1578-1582.
8. Gallo GF, Algire J, Srikandakumar A, et al. Effects of a prostaglandin F2α analogue on the ovulatory response of superovulated heifers. Anim Reprod Sci 1992; 27 (2-3): 83-90.
9. Randel RD, Lammoglia MA, Lewis AW, et al. Exogenous PGF2α enhanced GnRH-induced LH release in post-partum cows. Theriogenology 1996; 45 (3): 643-654.
10. Cruz LC, Do Valle ER, Kesler DJ. Effect of prostaglandin F2α and gonadotropin releasing hormone-induced luteinizing hormone releases on ovulation and corpus luteum function of beef cows. Anim Reprod Sci 1997; 49 (2-3): 135-142.
11. Gabriel HG, Wallenhorst S, Dietrich E, et al. The effect of prostaglandin F2α administration at the time of insemination on the pregnancy rate of dairy cows. Anim Reprod Sci 2011; 123 (1-2): 1-4.
12. Morrison DG, Chandler JE, Chandler LS, et al. Effect of prostaglandin F2α at insemination on sperm cell numbers and pregnancy rate in beef cattle. Theriogenology 1988; 30 (1): 109-118.
13. Sirois J, Sayasith K, Brown KA, et al. Cyclooxygenase-2 and its role in ovulation: a 2004 account. Hum Reprod Update 2004; 10 (5): 373-385.
14. Curry Jr TE, Malik A, Clark MR. Ovarian prostaglandin synthase: Immunohistochemical localization in the rat. Am J Obstet Gynecol 1987; 157 (3): 537-543.
15. Curry TE Jr, Bryant C, Haddix AC, et al. Ovarian prostaglandin endoperoxide synthase: cellular localization during the rat estrous cycle. Biol Reprod 1989; 42 (2): 307-316.
16. Hedin L, Gaddy-Kurten D, Kurten R, et al. Prostaglandin endoperoxide synthase in rat ovarian follicles: Content, cellular distribution, and evidence for hormonal induction preceding ovulation. Endocrinology 1987; 121 (2): 722-731.
17. Senger PL. Pathways to pregnancy and parturition. 3^rd ed. Pullman, USA: Current Conceptions Inc. 2012; 172-177.
18. Coulson A, Noakes DE, Hamer J, et al. Effect of gonadotrophin releasing hormone on levels of luteinising hormone in cattle synchronised with dinoprost. Vet Rec 1980; 107 (5): 108-109.
19. Nakao T, Shirakawa J, Tsurubayashi M, et al. A preliminary report on the treatment of ovulation failure in cows with gonadotropin-releasing hormone analog or human chorionic gonadotropin combined with insemination. Anim Reprod Sci 1984; 7 (6): 489-495.
20. Stevenson JS, Frantz KD, Call EP. Conception rates in repeat breeders and dairy cattle with unobserved estrus after prostaglandin F2α and gonadotropin releasing hormone. Theriogenology 1988; 29 (2): 451-460
21. Lee CN, Maurice E, Ax RL, et al. Efficacy of gonadotropin releasing hormone administered at the time of artificial insemination of heifers and postpartum and repeat breeder dairy cows. Am J Vet Res 1983; 44 (11): 2160-2163.
22. Morgan WF, Lean IJ. Gonadotrophin‐releasing hormone treatment in cattle: a meta‐analysis of the effects on conception at the time of insemination. Aus Vet J 1993; 70 (6): 205-209.
23. Bon Durant RH, Revah I, Franti C, et al. Effect of gonadotropin-releasing hormone on fertility in repeat-breeder California dairy cows. Theriogenology 1991; 35 (2): 365-374.
24. National research council. Nutrient requirements of dairy cattle. 7^th ed. Washington DC, USA: National Academies Press 2001; 381.
25. Colazo MG, Ambrose DJ, Kastelic J, et al. Comparison of 2 enzyme immunoassays and a radioimmunoassay for measurement of progesterone concentrations in bovine plasma, skim milk, and whole milk. Can J Vet Res 2008; 72 (1): 32-36.
26. Kauffold J, Gommel R, Failing K, et al. Postinsemination treatment of primiparous and multiparous cows with cloprostenol failed to affect ovulation and pregnancy rate in dairy cattle. Theriogenology 2009; 72 (5): 741-746.
27. Neglia G, Natale A, Esposito G, et al. Effect of prostaglandin F2α at the time of AI on progesterone levels and pregnancy rate in synchronized Italian Mediterranean buffaloes. Theriogenology 2008; 69 (8): 953-960.
28. Ullah G, Fuquay JW, Keawkhong T, et al. Effect of gonadotropin-releasing hormone at estrus on subsequent luteal function and fertility in lactating holsteins during heat stress. J Dairy Sci 1996; 79 (11): 1950-1953.
29. Mee MO, Stevenson JS, Alexander BM, et al. Administration of GnRH at estrus influences pregnancy rates, serum concentrations of LH, FSH, estradiol-17 beta, pregnancy-specific protein B, and progesterone, proportion of luteal cell types, and in vitro production of progesterone in dairy cows. J Anim Sci 1993; 71 (1): 185-198.
30. Lee CN, Critser JK, Ax RL. Changes of luteinizing hormone and progesterone for dairy cows after gonadotropin-releasing hormone at first postpartum breeding. J Dairy Sci 1985; 68 (6): 1463-1470.
31. Lucy MC, Stevenson JS. Gonadotropin-releasing hormone at estrus: Luteinizing hormone, estradiol, and progesterone during the periestrual and post-insemination periods in dairy cattle. Biol Reprod 1986; 35 (2): 300-311.
32. Ryan DP, Snijders S, Condon T, et al. Endocrine and ovarian responses and pregnancy rates in dairy cows following the administration of a gonadotrophin releasing hormone analog at the time of artificial insemination or at mid-cycle post insemination. Anim Reprod Sci 1994; 34 (3-4): 179-191.
33. López-Gatius F, Santolaria P, Martino A, et al. The effects of GnRH treatment at the time of AI and 12 days later on reproductive performance of high producing dairy cows during the warm season in northeastern Spain. Theriogenology 2006; 65 (4): 820-830.
34. Nielen M, Schukken YH, Scholl DT, et al. Twinning in dairy cattle: A study of risk factors and effects. Theriogenology 1989; 32 (5): 845-862.
35. Kinsel ML, Marsh WE, Ruegg PL, et al. Risk factors for twinning in dairy cows. J Dairy Sci 1998; 81 (4): 989-993.
36. Sauls JA, Voelz BE, Mendonça LGD, et al. Additional small dose of prostaglandin F2α at timed artificial insemination failed to improve pregnancy risk of lactating dairy cows. Theriogenology 2018; 110: 27-33.
37. Emadi SR, Rezaei A, Bolourchi M, et al. Administration of estradiol benzoate before insemination could skew secondary sex ratio toward males in Holstein dairy cows. Domest Anim Endocrinol 2014; 48: 110-118.

Veterinary Research Forum

Effect of prostaglandin F2α and GnRH administration at the time of artificial insemination on reproductive performance of dairy cows

References

References

Volume 10, Issue 2
June 2019
Pages 153-158

Effect of prostaglandin F2α and GnRH administration at the time of artificial insemination on reproductive performance of dairy cows

References

References

Volume 10, Issue 2June 2019Pages 153-158

Volume 10, Issue 2
June 2019
Pages 153-158