Ahur, V., Adenkola, Y., Saganuwan, S., Ikye-Tor, J. (2013). Ameliorative properties of aqueous extract of Ficus thonningii on erythrocyte osmotic fragility induced by acetaminophen in Rattus norvegicus. Veterinary Research Forum, 4(4), 207-212.
Victor Masekaven Ahur; Yahaya Adenkola Adenkola; Saganuwan Alhaji Saganuwan; Job Terungwa Ikye-Tor. "Ameliorative properties of aqueous extract of Ficus thonningii on erythrocyte osmotic fragility induced by acetaminophen in Rattus norvegicus". Veterinary Research Forum, 4, 4, 2013, 207-212.
Ahur, V., Adenkola, Y., Saganuwan, S., Ikye-Tor, J. (2013). 'Ameliorative properties of aqueous extract of Ficus thonningii on erythrocyte osmotic fragility induced by acetaminophen in Rattus norvegicus', Veterinary Research Forum, 4(4), pp. 207-212.
Ahur, V., Adenkola, Y., Saganuwan, S., Ikye-Tor, J. Ameliorative properties of aqueous extract of Ficus thonningii on erythrocyte osmotic fragility induced by acetaminophen in Rattus norvegicus. Veterinary Research Forum, 2013; 4(4): 207-212.
Ameliorative properties of aqueous extract of Ficus thonningii on erythrocyte osmotic fragility induced by acetaminophen in Rattus norvegicus
1Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Agriculture, Makurdi, Nigeria
2Division of Livestock Services, Benue State Ministry of Agriculture and Natural Resources, Makurdi, Nigeria
Abstract
Invitro antioxidant and erythrocyte protecting activities by aqueous extract of Ficusthonningiileaves on blood cells were studied in acetaminophen treated rats. The extract was safe at limit dose of 5000 mg kg-1body weight. The extract demonstrated dose dependent antihemolytic effect at dose levels between 50 and 200 mg kg-1 body weight. The lowest antihemolytic effect was observed at dose level of 200 mg kg-1 body given the lowest percentage hemolysis of 10.53 ± 1.76%, whereas the highest percentage hemolysis at dose level of 50 mg kg-1 was 29.02 ± 7.45%. Hematology revealed erythrocytosis at dose levels of 100 and 200 mg kg-1 body weight. Hyper-globinemia and lymphocytopenia were observed at dose levels of 100 mg kg-1 and 200 mg kg-1, respectively. The extract effectively showed scavenging activity on a stable oxidative radical diphenylpicrylhydrazyl (DPPH) and a significant ferric reducing antioxidant power (FRAP) activity. The plausible erythrocyte membrane protective effect may be due to its free radical scavenging activity and hence the extract can be used to improve hematological parameters and ameliorate oxidative stress.
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