The effectiveness of Teucrium chamaedrys L. extracts on endometriotic ‎implant regression in rat endometriosis model

Document Type : Original Article

Authors

1 Clinic of Gynecology, Zekai Tahir Burak Woman’s Health Training and Research Hospital, University of Health Sciences, Ankara, Turkey

2 Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey

3 Department of Pathology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

4 Laboratory Animals Care and Research Unit, Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey

Abstract

The aim of the present study was to investigate the therapeutic effects of Teucrium chamaedrys L. (Lamiaceae) in the experimentally induced endometriosis in rats. Endometrial tissue was implanted into the abdominal wall of thirty Sprague Dawley rats; the rats with endometriosis were randomized into five groups and treatment procedure was performed for three weeks. The treatment groups were orally treated with three different extracts of Teucrium chamaedrys. Buserelin acetate (20.00 mg) was given as a reference drug. Vehicle was administered alone to the control group. All rats were sacrified at the end of the experiment. The endometriotic implants were measured, intra-abdominal adhesions were scored and the tissue samples were histopathologically investigated. After the treatment procedure, the volumes of endometrial implant and adhesions were detected to be significantly decreased in the T. chamaedrys extracts treated groups compared to the control group. Therapeutic effect of the T. chamaedrys extracts could be attributed to the both nonpolar and polar secondary metabolites. The study conceived that the different polarity extracts of T. chamaedrys could be beneficial in the treatment of endometriosis.

Keywords


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