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Development of polyclonal heavy chain antibodies targeting programmed death ligand-1

Akbar Oghalaie; Alireza Shoari; Fatemeh Kazemi-Lomedasht; Fatemeh Rahimi-Jamnani; Fereidoun Mahboudi; Hajarossadat Ghaderi; Mohammad Hosseininejad-Chafi; Reza Moaazami; Arghavan Ashja Ardalan; Somayeh Piri-Gavgani; Delavar Shabazzadeh; Mahdi Behdani

Volume 14, Issue 6 , June 2023, , Pages 323-328

Abstract
  Programmed death ligand-1 (PD-L1, CD274 and B7-H1) has been described as a ligand for immune inhibitory receptor programmed death protein 1 (PD-1). With binding to PD-1 on activated T cells, PD-L1 can prevent T cell responses via motivating apoptosis. Consequently, it causes cancers immune evasion and ...  Read More