Volume 15 (2024)
Volume 14 (2023)
Volume 13 (2022)
Volume 12 (2021)
Volume 11 (2020)
Volume 10 (2019)
Volume 9 (2018)
Volume 8 (2017)
Volume 7 (2016)
Volume 6 (2015)
Volume 5 (2014)
Volume 4 (2013)
Volume 3 (2012)
Volume 2 (2011)
Volume 1 (2010)
Effect of thymoquinone on acetic acid-induced visceral nociception in rats: role of central cannabinoid and α2-adrenergic receptors

Somayyeh Naderi; Esmaeal Tamaddonfard; Saeid Nafisi; Farhad Soltanalinejad-Taghiabad

Volume 15, Issue 3 , March 2024, , Pages 131-138

  Thymoquinone (TQ) is the main biologically active substance of Nigella sativa (black seeds). It has anti-cancer, anti-inflammatory, anti-diabetic, anti-oxidative and anti-nociceptive properties. This study was aimed to explore the effect of TQ on acetic acid-induced visceral nociception. The central ...  Read More

Renal protection by ellagic acid in a rat model of glycerol-induced acute kidney injury

Maryam Khombi Shooshtari; Alireza Sarkaki; Mohammad Rashno; Khojasteh Hoseinynejad

Volume 15, Issue 2 , February 2024, , Pages 105-111

  Studies conducted on animal models have shown that the administration of glycerol can lead to kidney tissue damage and impaired renal function. This is believed to be caused by oxidative stress and inflammation, which in turn can result in elevated levels of blood urea nitrogen (BUN) and creatinine. ...  Read More

The CB1 cannabinoid receptors involvement in anti-epileptic effect of safranal on penicillin-induced epileptiform activity in rats

Sina Tamaddonfard; Amir Erfanparast; Esmaeal Tamaddonfard; Farhad Soltanalinejad

Volume 15, Issue 1 , January 2024, , Pages 35-41

  Neuroprotective effects for natural products are supported by several studies. In this regard, safranal, a constitute of saffron, has the potential to exert beneficial effects in neurological disorders such as Parkinson's disease, epilepsy, stroke, multiple sclerosis and Alzheimer's disease. Here, we ...  Read More

The autumn activity patterns and time budgets of Forest musk deer (Moschus berezovskii) in captivity

Songwei Lin; Liquan Shen; Haoxiang Gao; Jiayi Wu; Qingxin Lv; Xin Zhou; Junsheng Li; Xiuxiang Meng

Volume 14, Issue 11 , November 2023, , Pages 589-594

  Activity patterns and time budgets play a crucial role in the successful farming and management of animals. In this study, the behavior patterns of 53 forest musk deer (Moschus berezovskii) were analyzed from October 2nd to 16th, 2021, throughout the day and night. The results showed a distinct dawn–dusk ...  Read More

Cerebellar fastigial nucleus histamine and its H2 but not H1 receptors might inhibit acetic acid-induced visceral nociception and improve motor coordination in rats: role of opioid system

Fereshteh Anbarian; Esmaeal Tamaddonfard; Amir Erfanparast; Farhad Soltanalinejad-Taghiabad

Volume 14, Issue 10 , October 2023, , Pages 549-557

  The cerebellum and its deep nuclei contribute to the regulation of important functions including motor coordination and pain. Histamine modulates some functions of the fastigial nucleus (FN) such as motor coordination. In this study, by application of histamine and activation of its H1 and H2 receptors, ...  Read More

Attenuating effects of Mangifera indica leaves ethanolic extract against acetamiprid induced reproductive toxicity in male guinea pigs

Arthénice Jemima Nounamo Guiekep; Augustave Kenfack; Ferdinand Ngoula; Bertin Narcisse Vemo; Kenmeuhe Sidje Nguemmeugne; Etienne Pamo Tedonkeng

Volume 10, Issue 3 , September 2019, , Pages 187-192

  Acetamiprid (ACP) belonging to the neonicotinoid family used against wide array of pests in agriculture and domestic purposes. In this study, we evaluated the attenuating effects of ethanolic extract of Mangifera indica leaves (EEMI) in averting reproductive toxicity caused by ACP in male guinea pigs. ...  Read More

The effects of captopril on lipopolysaccharide-induced sickness behaviors in rats

Azam Abareshi; Akbar Anaeigoudari; Fatemeh Norouzi; Narges Marefati; Farimah Beheshti; Mohsen Saeedjalali; Mahmoud Hosseini

Volume 10, Issue 3 , September 2019, , Pages 199-205

  Neuro-immune mediators play an important role in the development of sickness behaviors. In the present study, the effect of captopril on sickness behaviors caused by lipopolysaccharide (LPS) was studied in the rats. The animals were randomized into the following groups: control, sham, 10 mg kg-1 captopril ...  Read More

Co-administration of retinoic acid and atorvastatin mitigates high-fat diet induced renal damage in rats

Leila Zarei; saied Mahdavi Rad; Amin Abollahzade Fard

Volume 10, Issue 2 , June 2019, , Pages 133-138

  Obesity causes many problems such as cardiovascular and chronic kidney diseases. The aim of this study was to evaluate the efficacy of retinoic acid and atorvastatin co-administration in kidneys protection against high-fat diet induced damage. Twenty-five male Wistar rats (200.00 ± 20.00 g) were ...  Read More

Effects of intracerebroventricular injection of vitamin B12 on formalin-induced muscle pain in rats: Role of cyclooxygenase pathway and opioid receptors

Esmaeal Tamaddonfard; Sina Tamaddonfard; Siamak Cheraghiyan

Volume 9, Issue 4 , December 2018, , Pages 329-335

  Vitamin B12 modulates pain at the local and peripheral levels. This study has investigated the effects of intracerebroventricular (ICV) injection of vitamin B12 on themuscle pain. We used diclofenac (cyclooxygenase inhibitor) and naloxone (opioid receptors antagonist) to clarify the possible mechanisms. ...  Read More

Stem Cells
Effect of extracellular matrix on testosterone production during in vitro culture of bovine testicular cells

Vahid Akbarinejad; Parviz Tajik; Mansoureh Movahedin; Reza Youssefi

Volume 8, Issue 1 , March 2017, , Pages 7-13

  Testosterone is believed to play a significant role in spermatogenesis, but its contribution to the process of spermatogenesis is not completely understood. Given that extracellular matrix (ECM) facilitates differentiation of spermatogonial stem cells (SSCs) during culture, the present study was conducted ...  Read More

Role of μ-opioid receptor in parafascicular nucleus of thalamus on morphine-induced antinociception in a rat model of acute trigeminal pain

Esmaeal Tamaddonfard; Amir Erfanparast

Volume 8, Issue 1 , March 2017, , Pages 29-34

  The parafascicular nucleus (PFN) of thalamus, as a supraspinal structure, has an important role in processing of nociceptive information. In addition, μ-opioid receptor contributes to supraspinal modulation of nociception. In the present study, the effects of microinjection of naloxone (a non-specific ...  Read More

Clinical Pathology
Hydrogen sulfide upregulated mRNA expressions of sodium bicarbonate cotransporter1, trefoil factor1 and trefoil factor2 in gastric mucosa in rats

Parisa Cheraghi; Seyyed Ali Mard; Tahereh Nagi

Volume 7, Issue 4 , December 2016, , Pages 323-328

  Hydrogen sulfide (H2S) has been shown to protect the gastric mucosa through several protective mechanisms but till now its effect on mRNA expression of sodium bicarbonate cotransporter 1 (NBC1), trefoil factor1 (TFF1) and trefoil factor2 (TFF2) was not investigated. This study was aimed to evaluate the ...  Read More

Clinical Pathology
Effect of soy milk on circulating 17- β estradiol, number of neurons in cerebral cortex and hippocampus and determination of their ratio in neonatal ovariectomized rats

Behrokh Marzban Abbasabadi; Mina Tadjalli

Volume 7, Issue 4 , December 2016, , Pages 347-351

  This study was conducted to evaluate the effect of soy milk on serum 17- β estradiol level and number of neurons in cerebral cortex and hippocampus as well as determination of the ratio of neurons in cortical and hippocampal regions in neonatal ovariectomized rats. Thirty female rats (one day old) ...  Read More

Effects of histidine and vitamin C on isoproterenol-induced acute myocardial infarction in rats

Masoumeh Moradi-Arzeloo; Amir Abbas Farshid; Esmaeal Tamaddonfard; Siamak Asri-Rezaei

Volume 7, Issue 1 , March 2016, , Pages 47-54

  In the present study, we investigated the effects of histidine and vitamin C (alone or in combination) treatments against isoproterenol (a β-adrenergic receptor agonist)-induced acute myocardial infarction in rats. We used propranolol (a β-adrenergic receptor blocker) to compare the results. ...  Read More

Evaluation of the anti-nociceptive effects of morphine, tramadol, meloxicam and their combinations using the tail-flick test in rats

Mehrzad Foroud; Nasser Vesal

Volume 6, Issue 4 , December 2015, , Pages 313-318

  The purpose of the present study was to evaluate anti-nociceptive effects of morphine, tramadol, meloxicam and their combinations in rats. Seventy male Wistar rats were divided into seven equal groups and randomly assigned to receive intraperitoneal saline (S) (control group, 1.0 mL kg-1), morphine (MO) ...  Read More

Role of opioid system in verapamil-induced antinociception in a rat model of orofacial pain

Esmaeal Tamaddonfard; Amir Erfanparast; Mina Taati; Milad Dabbaghi

Volume 5, Issue 1 , March 2014, , Pages 49-54

  Calcium, through its various channels involves in local, spinal and supra-spinal transmission of pain. In the present study, we investigated the separate and combined treatment effects of verapamil (a calcium channel blocker), morphine (an opioid agonist) and naloxone (an opioid antagonist) on pain in ...  Read More

Central Effect of Exogenous Histamine on Pain Induced by Sub-Plantar Injection of Formalin in Rabbits

Esmaeal Tamaddonfard

Volume 1, Issue 1 , June 2010, , Pages 1-6

  In the present study, the effects of intracerebroventricular (ICV) administration of normal saline (control), histamine, mepyramine (a histamine H1-receptor antagonist) and ranitidine (a histamine H2-receptor antagonist) were investigated on the formalin-induced pain in rabbits. Subcutaneous (SC) injection ...  Read More