TY - JOUR ID - 702466 TI - Tobacco smoke induces oxidative stress and alters pro-inflammatory cytokines and some trace elements in healthy indoor cats JO - Veterinary Research Forum JA - VRF LA - en SN - 2008-8140 AU - Demirtas, Berjan AU - Yanar, Karolin AU - Koenhemsi, Lora AU - Dusak, Nurcan Erozkan AU - Guzel, Ozlem AU - Kaymaz, Alev Akdogan AD - Department of Plant and Animal Production, Equine and Training Program, Vocational School of Veterinary Medicine, Istanbul University-Cerrahpaşa, Istanbul, Türkiye AD - Department of Medical Biochemistry, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Türkiye AD - Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University-Cerrahpaşa, Istanbul, Türkiye AD - Central Laboratory, Faculty of Veterinary Medicine, Istanbul University-Cerrahpaşa, Istanbul, Türkiye AD - Department of Surgery, Faculty of Veterinary Medicine, Istanbul University-Cerrahpaşa, Istanbul, Türkiye Y1 - 2023 PY - 2023 VL - 14 IS - 6 SP - 301 EP - 308 KW - antioxidants KW - Cotinine KW - Cytokines KW - Passive Smoking KW - pet animals DO - 10.30466/vrf.2022.545424.3357 N2 - This study was aimed to assess oxidative stress, pro-inflammatory cytokines and some trace elements in healthy pet cats exposed to environmental tobacco smoke. Forty healthy cats were included in this study. Cats were divided in two groups: Exposed to tobacco smoke (ETS; n = 20) and non-exposed to tobacco smoke (NETS; n = 20). Blood levels of cotinine, total oxidant status (TOS), oxidative stress index (OSI), lipid hydroperoxide (LOOH), protein carbonyl (PCO), advanced oxidative protein products (AOPP), total antioxidant status (TAS), copper, zinc-superoxide dismutase (Cu, Zn-SOD), catalase (CAT), total thiol (T-SH), interferon gamma (INF-γ), tumor necrosis factor (TNF-α), interleukin β (IL-1β), interleukin 6 (IL-6), interleukin-8 (IL-8), interleukin 2 (IL-2) and iron (Fe), zinc (Zn), copper (Cu), selenium (Se) levels were measured. Hematological and biochemical parameters were also measured. Serum cotinine, TOS, OSI, PCO, AOPP and LOOH levels were higher, whereas TAS and Cu, Zn-SOD levels were lower in ETS group. In ETS group INF-γ, IL-1β, IL-2, and IL-6 levels were higher. The Cu level was higher in ETS group. Blood reticulocyte number, serum creatinine and glucose were higher in ETS group. It could be concluded that exposure to tobacco smoke in cats impaired the oxidant/antioxidant balance and potentially triggered the release of pro-inflammatory cytokines. UR - https://vrf.iranjournals.ir/article_702466.html L1 - https://vrf.iranjournals.ir/article_702466_be57e4bdcb92493fb0aabc3afc2dc68c.pdf ER -