Faculty of Veterinary Medicine, Urmia University Veterinary Research Forum 2008-8140 12 1 2021 03 15 ‎In vitro‎ assessment of anti-Trichomonas effects of Zingiber officinale‏ ‏and ‎Lavandula angustifolia alcoholic extracts on Trichomonas gallinae 95 100 240931 10.30466/vrf.2019.102620.2444 EN Farnaz Malekifard Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Mosa Tavassoli Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran 0000-0002-0169-6041 Mohammad Alimoradi Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Journal Article 2019 01 25 Trichomonas gallinae is a parasite that acts as a canker-causing agent and leads to significant loss and mortality, especially in young birds. Metronidazole is the approved drug used for the treatment of trichomoniasis. A non-chemical alternativess such as medical plant extracts are also used to treat this disease due to drug resistance. This study aimed to assess in vitro antitrichomonal effects of Lavandula angustifolia and Zingiber officinale extracts on T. gallinae compared with metronidazole. The T. gallinae samples were obtained from infected pigeons. Multi-well plates filled with different concentrations (5.00, 10.00, 25.00, 50.00, and 100 μg mL-1) were used to perform in vitro analysis. The Z. officinaleextract’s minimum inhibitory concentration (MIC) in the 24-hr period was 25.00 μg mL-1, while it was 50.00 μg mL-1 for metronidazole. The MIC value obtained for L. angustifolia extract in 24-hr was 50.00 μg mL-1. The results indicated that the extracts of Z. officinaleand L. angustifolia could act as potential natural agents against trichomoniasis. Furthermore, this study delineated the equal efficiency of L. angustifolia and Z. officinale with that of metronidazole in inhibiting the growth of Trichomonas gallinae trophozoites in culture media.

https://vrf.iranjournals.ir/article_240931_e8b102c2d4bf2b32895e528ce3248323.pdf