Faculty of Veterinary Medicine, Urmia University Veterinary Research Forum 2008-8140 15 6 2024 06 01 Clinical and echocardiographic evaluations of sedative and cardiovascular effects of combination of xylazine-acepromazine versus xylazine-pregabalin in horses 291 296 713207 10.30466/vrf.2024.2013359.4034 EN Siamak Shokrollahi Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Rahim Mohammadi Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran 0000-0002-2104-9829 Farshid Sarrafzadeh-Rezaei Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran 0000-0003-4692-3831 Ghader Jalilzadeh-Amin Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran 0000-0003-2869-5492 Seyed Mohammad Hashami-Asl Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran 0000-0003-3909-2144 Journal Article 2023 10 11 The aim of this study was to compare the sedative and cardiovascular effects of the combination of xylazine-acepromazine versus xylazine-pregabalin - in horses. Four healthy crossbred horses were included in the study and assigned to two treatments. In treatment I (T1), the animals received xylazine hydrochloride (1.00 mg kg<sup>-1</sup>) in combination with acepromazine maleate (0.05 mg kg<sup>-1</sup>) intravenously. In treatment II (T2), the animals received intragastric administration of pregabalin (4.00 mg kg<sup>-1</sup>) followed by xylazine hydrochloride (1.00 mg kg<sup>-1</sup>) intravenously after 60 min. Head height above ground (HHAG) and echocardiographic indices were evaluated. In T1, recordings were made 5 minubefore and 5, 15, 30, 60, and 90 minu after drug administration. In T2, recordings were made 5 min before pregabalin, 55 minu after pregabalin administration, and then 5, 15, 30, 60, and 90 min after xylazine hydrochloride acepromazine injection. Analyses of the data showed there were no significant differences regarding HHAG and echocardiographic indices between the two treatments. Intragastric administration of pregabalin prior to xylazine could be considered as an alternative premedication regimen when acepromazine administration is contraindicated or undesirable. Acepromazine Echocardiography Pregabalin Sedation Xylazine https://vrf.iranjournals.ir/article_713207_25bca046ca3abe424e3452b1d02bf5c8.pdf