Large Animal Internal Medicine
Mohammad Farajli Abbasi; Bahador Shojaei; Omid Azari
Volume 8, Issue 4 , December 2017, , Pages 361-363
Abstract
Congenital agenesis of lumbar vertebrae was diagnosed in a day-old female lamb based on radiology and clinical examinations. There was no neurological deficit in hindlimb and forelimb associated with standing disability. Radiography of the abdominal region revealed absence of lumbar vertebrae. Necropsy ...
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Congenital agenesis of lumbar vertebrae was diagnosed in a day-old female lamb based on radiology and clinical examinations. There was no neurological deficit in hindlimb and forelimb associated with standing disability. Radiography of the abdominal region revealed absence of lumbar vertebrae. Necropsy confirmed clinical and radiographic results. No other anomaly or agenesis was seen macroscopically in the abdominal and thoracic regions as well as vertebral column. Partial absence of vertebral column has been reported in human and different animal species, as an independent occurrence or associated with other organs anomalies. The latter has been designated as caudal regression syndrome. Vertebral agenesis may arise from irregularity in the differentiation of somites to the sclerotome or sclerotome to the vertebral primordium. Most of the previously reported cases of agenesis were related to the lumbosacral region, lonely or along with other visceral absences. This case was the first report of congenital agenesis of lumbar vertebrae in a lamb.
Ehsanollah Sakhaee; Homayoon Babaei; Jalil Abshenas; Omid Azari; Reza Kheirandish; Farideh Ebrahimi-Meymand
Volume 2, Issue 4 , December 2011, , Pages 232-237
Abstract
In this study we investigated histopathological changes of mice ovarian tissues following long-term administration of copper sulfate and induction of chronic copper poisoning. The study comprised of three different groups of twenty one mice as follows: The first group (Group 100) which treated by gavage ...
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In this study we investigated histopathological changes of mice ovarian tissues following long-term administration of copper sulfate and induction of chronic copper poisoning. The study comprised of three different groups of twenty one mice as follows: The first group (Group 100) which treated by gavage with copper sulfate at a dose of 100 mg kg-1 for 5 weeks. The second group (Group 200), which received 200 mg kg-1 copper sulfate by gavage during experimental period (35 days), and control animals (Group C), which received the same volume of distilled water in the same way. The blood samples were obtained from 7 cases out of 21 animals of each group by cardiac puncture at the end of first, third and fifth week. Ovarian lesions were observed in group 100 after 35th day and in group 200 after 21st day. The histopathologic examination revealed widespread ovarian follicle atresia in group 200 after 35th day Atretic follicles had numerous cell debris and inflammatory cells in the antral cavity. In degenerative antral follicles granulose cells degenerated and desquamated into antrum. In some degenerative antral follicles infiltration of inflammatory cells into granulose cell layer and antrum were observed. The histopathlogic data indicate the possibility of adverse effect of copper poisoning on the mice ovarian tissue. Copper might be mediator of the effect of oxidative damage and play an essential role in reproductive system.