Veterinary Research Forum
Vet Res Forum

Evaluation of Anti-ulcer Activity of Echinops Persicus on Experimental Gastric Ulcer Models in Rats

Document Type : Original Article

Authors

Ali Asadi Rad 1
Hossein Najafzadeh-Varzi 2
Ahmad Farajzadeh-Sheikh 3

1 Educated from Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

2 Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

3 Department of Medical Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract
Extract of Echinops persicus is traditionally used for a long time in Iran for treatment of cough and constipation. This extract is produced by activity of bug (Situphilus spp.) on the plant. We documented its anti-tussive effect in rats in our previous study. The aim of this study was to assess the anti-ulcer effect of Echinops persicus in an animal model. In this study we evaluated anti-ulcer effect of Echinops persicus by Shay's method in rats. In 3 groups of rats, pylorus was ligatured under anesthesia. The rats were euthanized after 19 hours later and number and level of ulcer in stomach was measured. In group 2 the extract was orally administered 45 minutes before pyloric ligature, and in group 3, it was administered intraperitoneally 20 minutes before pyloric ligature. The number of ulcers in stomach was significantly low in group 2 (P = 0.01) and 3 (P = 0.037) in comparison with group 1. The level of ulcer was significantly decreased in group 2 (P = 0.047) with comparison to group 1. We conclude that, Echinops extract can exhibit potentially cytoprotective and anti-ulcer activity.

Keywords

Echinops persicus
Anti- ulcer
Pyloric ligature
Helicobacter pylori
Veterinary Research Forum
Volume 1, Issue 3 - Serial Number 3
December 2010
Pages 188-191

  • Receive Date 26 December 2012

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