Document Type : Original Article
department of clinical sciences, Ferdowsi university of Mashhsd, Iran.
Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
In order to investigate the hormonal and biochemical profiles of horses with osteochondrosis dissecans(OCD) , serum insulin, cortisol , T3, T4, Fasting blood Glucose (FBG), cholesterol, triglyceride (TG), HDL, LDL, albumin and uric acid were measured in horses definitely diagnosed as having OCD (no.19) as well as clinically normal horses (no.18). Proxies representing insulin sensitivity [Reciprocal of square root of insulin concentration (RISQI)] and beta cell responsiveness [modified insulin to glucose ratio (MIRG)] were calculated. Body fat percent (BF %) was estimated according to fat depth over the rump, determined using ultrasonography. Body condition score (BCS), weight, and waist circumference were also determined. Glucose was significantly higher and MIRG, BCS, BF% and TG were significantly lower in OCD- horses than control group. Based on BCS scores, horses in control group were overweight. The result of the present study, higher FBG and lower MIRG may implicate the existence of a footmark of insulin/glucose derangement. The Body mass index and muscle mass were not measured in this study, nonetheless, a lower BF% may implicate a higher body muscle mass in OCD affected horses, which were comparably underweight than control group. While insulin resistance does also occur in human individuals and horses with lower BF%, horses with higher muscle mass may show greater potential for exercise, which in turn, exerts greater physical pressure on cartilages. An underlying hormonal predisposition could make these horses more prone to OCD, originally triggered by mechanical pressures.