Veterinary Research Forum
Vet Res Forum

Metastatic giant cell osteosarcoma in a cat

Document Type : Clinical Report

Authors

Ghasem Farjanikish 1
Omid Dezfoulian 1
Hossein Mohammadi 2

1 Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran

2 Department of Pathology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

https://doi.org/10.30466/vrf.2018.32087
Abstract
A four-year-old male Persian cat was referred with three weeks history of progressive lameness due to a rigid osseous mass with 3.50×2.50×2.00 cm in dimensions in his left arm. In the histopathological evaluation of bone biopsy, two distinct populations of cells including multinucleated giant cells and oval cells which embedded in a fibro-osseous stroma and surrounded by lamellar bone trabeculae were observed. At necropsy, multiple metastatic nodules with different sizes unveiled in the liver and spleen. Microscopically, those tumor cells which already described in the bone lesion were also infiltrated to the liver and spleen. The neoplastic cells had no immunoreaction to CD68, desmin, alpha smooth muscle actin, S100, CD20, CD3 and pancytokeratin, but only a few cells had reaction to vimentin were similar to fibroblasts.

Keywords

Giant cell osteosarcoma
Immunohistochemistry
Metastasis
Persian cat

Subjects

  1.  

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Veterinary Research Forum
Volume 9, Issue 3
Summer 2018
Pages 289-292

  • Receive Date 15 August 2018

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