Metastatic giant cell osteosarcoma in a cat

Document Type: Clinical Report

Authors

1 Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran

2 Department of Pathology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Abstract

A four-year-old male Persian cat was referred with three weeks history of progressive lameness due to a rigid osseous mass with 3.50×2.50×2.00 cm in dimensions in his left arm. In the histopathological evaluation of bone biopsy, two distinct populations of cells including multinucleated giant cells and oval cells which embedded in a fibro-osseous stroma and surrounded by lamellar bone trabeculae were observed. At necropsy, multiple metastatic nodules with different sizes unveiled in the liver and spleen. Microscopically, those tumor cells which already described in the bone lesion were also infiltrated to the liver and spleen. The neoplastic cells had no immunoreaction to CD68, desmin, alpha smooth muscle actin, S100, CD20, CD3 and pancytokeratin, but only a few cells had reaction to vimentin were similar to fibroblasts.

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  1. Fletcher CDM, Unni KK, Mertens F. World health organization classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon, France: International Agency for Research on Cancer (IARC) 2002; 264-286.
  2. Schulz, K. Other diseases of bones and joints. In: Fossum TW (Ed). Small animal surgery. Philadelphia, USA: WB Saunders 2008; 1333-1356.
  3. Thompson KG, Pool RR: Tumors of bones. In: Meuten DJ. Tumors in domestic animals. 4th ed. Ames, USA: Iowa State Press 2002; 268-296.
  4. Verma RK, Gupta G, Bal A, et al. Primary giant cell rich osteosarcoma of maxilla: An unusual case report. J Oral Maxillofac Surg 2011; 10: 159-162.
  5. Holmberg BJ, Farese JP, Taylor D, et al., Osteosarcoma of the humeral head associated with osteocondritis dissecans in a dog. J Am Anim Hosp Assoc 2004; 40(3): 246-249.
  6. Oryan A, Sadoughifar R, Shirian S, et al. Giant cell-rich osteosarcoma of tibia in a dog: a pathological and immunohistochemical study. Comp Clin Pathol 2015; 24: 177-179.
  7. Heldmann E, Anderson MA, Wagner-Mann C. Feline osteosarcoma: 145 cases (1990–1995). J Am Anim Hosp Assoc 2000; 36:518-521.
  8. Gambarotti M, Donato M, Alberghini M, et al. A strange giant cell tumor. Eur J Radiol 2011; 77: 3-5.
  9. Withrow SJ, MacEwen EG. Small animal clinical oncology. 2nd ed. Philadelphia, USA: WB Saunders 1996; 287-315.
  10. Fu HH, Zhuang QW, He J. Giant cell-rich osteosarcoma or giant cell reparative granuloma of the mandible? J Craniofac Surg 2011; 22: 1136-1139.
  11. Shimose S, Sugita T, Kubo T, et al. Differential diagnosis between osteomyelitis and bone tumors. Acta Radiol 2008; 49: 928-933.
  12. Cristo TG, Vargas CB, Biezus G, et al. Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog. Braz J Vet Pathol 2017; 10(3): 105-110
  13. Kirpensteijn J, Van den Bos R, Endenburg N. Adaption of dogs to the amputation of a limb and their owners’ satisfaction with the procedure. Vet Rec 1999; 144: 115-118.
  14. Brodey, RS; Riser, WH. Canine osteosarcoma: A clinicopathologic study of 194 cases. Clinical Orthopedics 1969; 62(4): 26-32.
  15. Mueller F, Fuchs B, Kaser-Hotz B. Comparative biology of human and canine osteosarcoma. Anticancer Res 2007; 27(1A):155-164.
  16. Kirpensteijn J, Kik M, Rutteman G R, Teske E. Prognostic significance of a new histologic grading system for canine osteosarcoma. Vet Pathol 2002; 39:240-246.
  17. Cerilli L, Wick M. Immunohistology of soft tissue and osseous neoplasms. In: Dabbs DJ (Ed). Diagnostic immunohistochemistry. New York, USA: Chruchill Livingstone 2002; 72-73.