Influence of tramadol on anesthesia times, analgesia and electrocardiogram associated with injection anesthesia in common buzzards (Buteo buteo)

Document Type: Original Article

Authors

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Lorestan, Iran

2 Student of Veterinary Medicine, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran

Abstract

A balanced anesthesia protocol is called perfect when it has fast induction, excellent recovery, the least effect on the cardiopulmonary system and sufficient analgesia. Many of anesthetic combinations have an analgesic effect without opioids. However, at the end of anesthesia, analgesia decreases or is incomplete. The purpose of this study was to evaluate anesthesia times, electrocardiogram (ECG) and analgesic effect of tramadol when administrated with ketamine, ketamine-diazepam, ketamine-midazolam, and ketamine-xylazine and selected a balanced anesthesia protocol in buzzards. Ten adult common buzzards (Buteo buteo) received seven different anesthetic protocols (with or without tramadol). In each protocol, anesthesia times, electrocardiograph parameters and analgesic effect were recorded. Excluding ketamine-tramadol, all protocols produced deep anesthesia in all buzzards. Among of all protocols, no significant differences regarding the amplitude and duration of waves (P, QRS and T) was found. By adding tramadol to anesthetic protocols, response duration to thermal sense increased up 3 hr after recovery. Tramadol did not make considerable effects on anesthesia times and ECG and made analgesic effect up to 3 hr when used with ketamine-benzodiazpins or ketamine-xylazine. Therefore, tramadol can be used with injectable anesthetics to make suitably balanced anesthesia in buzzards.

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  1. Muir WW. Considerations for general anesthesia. In: Tranquilli WJ, Thurmon JC, Grimm KA, (Eds). Lumb & Jones' veterinary anesthesia and analgesia. 4th ed. Ames, USA: Blackwell Publishing 2007; 7-31.
  2. Ludders JW, Matthews NS. Birds. In: Tranquilli WJ, Thurmon JC, Grimm KA, (Eds). Lumb & Jones' veterinary anesthesia and analgesia. 4th ed. Ames, USA: Blackwell Publishing 2007; 841-868.
  3. Espino L, Suárez ML, López-Beceiro A, et al. Electrocardiogram reference values for the buzzard in Spain. J Wild Dis 2001; 37(4): 680-685.
  4. Araghi M, Azizi S, Vesal N, et al. Evaluation of the sedative effects of diazepam, midazolam, and xylazine after intranasal administration in juvenile ostriches (Struthio camelus). J Avian Med Surg 2016; 30(3):221-226.
  5. BighamSadegh A, Shafiei Z, Mahmoudi T, et al. Ketamine-xylazine with diazepam or midazolam anesthesia in eagles (Aquila Chrysaetos). Online J Vet Res 2011; 15 (4): 414-419.
  6. Javdani M, Ghashghaei A, Nikousefat Z. Evaluation of anesthetic and analgesic effect of ketamine in combination of tramadol, midazolam, hyoscine, and atropine in broiler chickens. J Vet Med 2012; 6(1):11-17.
  7. Vesal N, Eskandari MH. Sedative effects of midazolam and xylazine with or without ketamine and detomidine alone following intranasal administration in ring-necked Parakeets. J Am Vet Med Assoc 2006; 228: 383-388.
  8. Paul-Murphy J. Evaluating the analgesic effects of opioids in birds. A cross species approach to pain and analgesia. International Veterinary Information Service, Ithaca, USA, Available at: www.ivis.org. Accessed 28 Feb, 2018.
  9. Hellyer PW, Robertson SA, Fails AD: Pain and its management. In: Tranquilli WJ, Thurmon JC, Grimm KA, (Eds). Lumb & Jones' veterinary anesthesia and analgesia. 4th ed. Ames, USA: Blackwell Publishing 2007; 33-60.
  10. Barletta M, Austin BR, Ko JC, et al. Evaluation of dexmedetomidine and ketamine in combination with opioids as injectable anesthesia for castration in dogs. J Am Vet Med Assoc 2011; 238(9):1159-1167.
  11. Buitrago S, Martin TE, Tetens-Woodring J, et al. Safety and efficacy of various combinations of injectable anesthetics in Balb/c mice. J Am Assoc Lab Anim Sci 2008; 47(1):11-17.
  12. Souza MJ, Martin-Jimenez T, Jones MP et al. Pharmacokinetics of intravenous and oral tramadol in the bald eagle (Haliaeetus leucocephalus). J Avian Med Surg 2009; 23(4): 247-252.
  13. Souza MJ, Martin Jimenez T, Jones MP, et al. Pharmacokinetics of oral tramadol in red-tailed hawks (Buteo jamaicensis). J Vet Pharmacol Ther 2010; 34(1):86-88.
  14. Souza MJ, Guzman DSM, Paul-Murphy JR, et al. Pharmacokinetics after oral and intravenous administration of a single dose of tramadol hydro-chloride to Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res 2012; 73(8):1142-1147.
  15. Souza MJ, Gerhardt L, Cox S. Pharmacokinetics of repeated oral administration of tramadol hydroc-hloride in Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res 2013; 74(7): 957-962.
  16. Guzman DSM, Drazenovich TL, Olsen GH, et al. Evaluation of thermal antinociceptive effects after oral administration of tramadol hydrochloride to American kestrels (Falco sparverius). Am J Vet Res 2014; 75(2):117-123.
  17. Guzman DSM, Souza MJ, Braun JM, et al. Antinociceptive effects after oral administration of tramadol hydrochloride in Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res 2012; 73(8):1148-1152.
  18. Geelen S, Guzman DSM, Souza MJ, et al. Antinociceptive effects of tramadol hydrochloride after intravenous administration to Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res 2013; 74(2): 201-206.
  19. Eyarefe OD, Oguntoye CO. Effects of varying doses of tramadol on ketamine anaesthesia for laparocecectomy in layer chickens. J Vet Med Anim Health 2015; 7(12): 331-339.
  20. Hedley J. Anesthesia in exotics. Part 2: Birds. Vet Nurse J 25; 2010: 24-27.
  21. Raeisi A, Taati M, Rostami M, et al. Anesthesia and sedation in Chough (Pyrrhocorax pyrrhocorax) following intranasal administration of diazepam, midazolam, xylazine with or without ketamine: Clinical evaluation. Iran J Vet Surg 2016; 11(1): 23-27.
  22. LierzM, Korbel M. Anesthesia and analgesia in birds. J Exot Pet Med 2016; 21(1): 44-58
  23. Heatley JJ. Anesthesia and analgesia. In: Chitty J, Lierz M (Eds). BSAVA manual of raptors, pigeons and passerine birds. Gloucester, UK; BSAVA Publishing 2008; 97-113.
  24. Kilic N, Pasa S. Cardiopulmonary effects of propofol compared with those of a medetomidine-ketamine combination in the common buzzards (Buteo buteo). Revue Med Vet 2009; 160(3): 154-159.
  25. Rafiei M, Taati M, Alavi S, et al. Effects of intracerebro-ventricular injection of histamine and H1, H2 receptor antagonists on electrocardiographic parameters in broiler chickens. Iran J Vet Res 2011; 12(3):192-198.
  26. Hothersall B, Caplen G, Nicola CJ, et al. Development of mechanical and thermal nociceptive threshold testing devices in unrestrained birds (broiler chickens). J Neurosci Methods 2011; 201(1): 220- 227.
  27. Duvall A. Tramadol. J Exot Pet Med 2017; 26 (1): 74-77.
  28. Miller W, Buttrick M. Current anesthesia recommendations for companion birds. Iowa State University Veterinarian 1999; 61(2): 67-75.
  29. Varner J, Clifton KR, Poulos S, et al. Lack of efficacy of injectable ketamine with xylazine or diazepam for anesthesia in chickens. Lab Animal 2004; 33(5): 36-39.
  30. Sandmeier P. Evaluation of medetomidine for short-term immobilization of domestic pigeons (Columba livia) and Amazon parrots (Amazona species). J Avian Med Surg 2000; 14(1): 8-14.
  31. Atalan G, Uzun M, Demirkan S, et al. Effect of medetomidine-butorphanol-ketamine anesthesia and atipamezole on heart and respiratory rate and cloacal temperature of domestic pigeons. J Vet Med A Physiol Pathol Clin Med 2002; 49(6): 281-285.
  32. Hassanpour H, Moghaddam AK, Cheraghchibashi M. The normal electrocardiogram of conscious golden eagles (Aquila chrysaetos). J Zoo Wild Med 2010; 41 (3): 426-431.
  33. Raina R, Verma PK, Pankaj NK, et al. Effects of tramadol on electrocardiogram, mean electrical axis and respiration in Kagani goats (Capra hircus). Iran J Pharmacol Ther 2008; 7(2):157-160.
  34. Andersen HT. Hyperpotassemia and electro-cardiographic changes in the duck during prolonged diving. Acta Physiol Scand 1965; 63: 292-295. 
  35. Blanko JM. Avian electrocardiography: A contribution for the practitioner. In Proceedings: European conference on avian medicine and surgery. European committee of the association of avian veterinarians, Utrecht, the Netherlands 1993; 137-154.
  36. Borer-Weir K. Analgesia. In: Hall LW, Clarke KW, Trim CM (Eds). Veterinary anesthesia. 11th ed. Philadelphia, USA: WB Saunders 2014; 102-126.
  37. Ajadi RA, Olusa TA, Smith OF, et al. Tramadol improved the efficacy of ketamine-xylazine anesthesia in young pigs. Vet Anesth Analg 2009; 36 (6): 562-566.