Veterinary Research Forum
Vet Res Forum

Clinicopathologic findings in rats fed on the powder of Caloncoba echinata leaves

Document Type : Short Communication

Authors

Christian Onwuchokwe Okorie-Kanu 1
Daniel Inua Edet 1
Patrick Emeka Aba 2
Onyinye Josephine Okorie-Kanu 3

1 Department of Veterinary Pathology, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria

2 Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria

3 Department of Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria

https://doi.org/10.30466/vrf.2018.89652.2170
Abstract
This study investigated the toxic effects of dried pulverized Caloncoba echinata leaves on the hematology, blood biochemistry and vital organs of male albino rats. Twenty adult male rats were randomly divided into four groups of five rats each. Groups A, B and C were fed 25.00%, 15.00% and 5.00% of pulverized C. echinata leaves in feed respectively while group D was given normal feed for a four weeks period. Blood samples were collected at two weeks intervals for hematological and blood biochemistry analyses. Results showed a significant reduction of packed cell volume, hemoglobin concentration and total red blood cell counts in group B from week two to the end of the study. There was also a reduction of body weight and leukocytosis in groups A and B from week two to the end of the study. There was a significant reduction of albumin in group B when compared to the other groups after two weeks and a significant reduction in blood glucose concentration in group A after two weeks of the feeding of the leaves to the end of the study. Discrete areas of degeneration and necrosis of hepatocytes were observed in the rats of groups A and B and testicular atrophy in group B rats. It was concluded that feeding the rats with the pulverized C. echinata leaves led to a significant reduction of body weights and erythrocytic parameters, leukocytosis, hepatic and testicular injuries in the albino rats.

Keywords

Blood biochemistry
Caloncoba echinata
Hematology
Histopathology
Rats

Subjects

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Veterinary Research Forum
Volume 10, Issue 4
Autumn 2019
Pages 351-355

  • Receive Date 28 August 2018
  • Revise Date 28 December 2018
  • Accept Date 30 December 2018

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