Document Type : Clinical Report
Authors
- Belalmi Nor El Houda 1
- Sid Nassim 2
- Omar Bennoune 1
- Ouhida Soraya 3
- Marcelo De Las Heras 4
- Caroline Leroux 5
1 Laboratory of Health, Animal Production and Environment, Department of Veterinary Medicine, Institute of Veterinary and Agricultural Sciences, University of Batna, Batna, Algeria
2 Institute of Veterinary Sciences, Frères Mentouri University, El khroub, Algeria
3 University Hospital Center Saadna Mohamed Abdennour, Setif, Algeria
4 Department of Animal Pathology, Faculty of Veterinary Medicine, University of Zaragoza, Zaragoza, Spain
5 Viral Infections and Comparative Pathology, National Institute of Agronomic Research, University Claude Bernard Lyon, France
Abstract
We report the occurrence of lung cancer in a six months old lamb of Ouled Djellal breed from Algeria. The main clinical sign was a considerable amount of whitish foamy fluid discharge from the nostrils when the animal head was lowered and the rear end was lifted. The post-mortem examination revealed the presence of enlarged, heavy and edematous lungs with diffuse or foci areas, reddish or white-gray in color. The gross and histological lesions of the lungs were compatible with pulmonary adenocarcinoma. Lung adenocarcinoma in sheep is caused by jaagsiekte sheep retrovirus (JSRV) and originated from differentiated alveolar type II cells and non-ciliated bronchiolar epithelial Clara cells. We evidenced the expression of the oncogenic JSRV by immunostaining of lung slides with specific antibodies against the JSRV envelope. The viral proteins were expressed only in the tumor cells from the affected areas. As already described in other countries, JSRV-induced lung adenocarcinoma is present in the sheep population in Algeria.
Keywords
- Griffiths DJ, Martineau HM, Cousens C. Pathology and pathogenesis of ovine pulmonary adenocarcinoma. J Comp Pathol 2010; 142(4): 260-283.
- York DF, Querat G. A history of ovine pulmonary adenocarcinoma (jaagsiekte) and experiments leading to the deduction of the JSRV nucleotide sequence. Curr Top Microbiol Immunol 2003; 275: 1-23.
- Sharp JM, Demartini JC. Natural history of JSRV in sheep. Curr Top Microbiol Immunol 2003; 275: 55-79.
- Sanna MP, Sanna E, De Las Heras M, et al. Association of jaagsiekte sheep retrovirus with pulmonary carcinoma in Sardinian moufflon (Ovis musimon). J Comp Pathol 2001; 125(2-3): 145-152.
- De Las Heras M, González L. Sharp JM. Pathology of ovine pulmonary adenocarcinoma. Curr Top Microbiol Immunol 2003; 275: 25-54.
- Verwoerd DW, Payne AL, York DF, et al. Isolation and preliminary characterization of the jaagsiekte retro- virus (JSRV). Onderstepoort J Vet Res 1983; 50: 309-316.
- York DF, Vigne R, Verwoerd DW, et al. Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats. J Virol1992; 66(8): 4930-4939.
- Monot M, Archer F, Gomes M, et al. Advances in the study of transmissible respiratory tumours in small ruminants. Vet Microbiol 2015; 181(1-2): 170-177.
- Sid N, Belalmi NEH, Benhamza L, et al. First case report of enzootic nasal adenocarcinoma in "Ouled Djellal" ewe in Algeria. Open Vet J 2018; 8(1): 9-12.
- De Las Heras M, De Martino A, Borobia M, et al. Solitary tumours associated with Jaagsiekte retrovirus in sheep are heterogeneous and contain cells expressing markers identifying progenitor cells in lung repair. J Comp Pathol 2014; 150 (2-3): 138-147.
- Kardjadj M, Luka PD. Current Situation of Milk and Red Meat Industry in Algeria. J Nutr Food Sci 2016; 6(4).
- Caporale M, Centorame P, Giovannini A, et al. Infection of lung epithelial cells and induction of pulmonary adenocarcinoma is not the most common outcome of naturally occurring JSRV infection during the commercial lifespan of sheep. Virology 2005; 338(1): 144-153.
- Dungal N. Epizootic adenomatosis of the lungs of sheep: Its relation to verminous pneumonia and Jaagsiekte. Proc Roy Soc Med 1983; 31: 497-505.
- Grego E, De Meneghi D, Alvarez V, et al. Colostrum and milk can transmit jaagsiekte retrovirus to lambs. Vet Microbiol 2008; 130(3-4): 247-257.
- Borobia M, De Las Heras M, Ramos JJ, et al. Jaagsiekte sheep retrovirus can reach Peyer's patches and mesenteric lymph nodes of lambs nursed by infected mothers. Vet Pathol 2016; 53(6): 1172-1179.
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