Evidence of jaagsiekte sheep retrovirus-induced pulmonary adenocarcinoma in Ouled Djellal breed sheep in Algeria

Document Type: Clinical Report

Authors

1 Laboratory of Health, Animal Production and Environment, Department of Veterinary Medicine, Institute of Veterinary and Agricultural Sciences, University of Batna, Batna, Algeria

2 Institute of Veterinary Sciences, Frères Mentouri University, El khroub, Algeria

3 University Hospital Center Saadna Mohamed Abdennour, Setif, Algeria

4 Department of Animal Pathology, Faculty of Veterinary Medicine, University of Zaragoza, Zaragoza, Spain

5 Viral Infections and Comparative Pathology, National Institute of Agronomic Research, University Claude Bernard Lyon, France

10.30466/vrf.2019.107160.2549

Abstract

We report the occurrence of lung cancer in a six months old lamb of Ouled Djellal breed from Algeria. The main clinical sign was a considerable amount of whitish foamy fluid discharge from the nostrils when the animal head was lowered and the rear end was lifted. The post-mortem examination revealed the presence of enlarged, heavy and edematous lungs with diffuse or foci areas, reddish or white-gray in color. The gross and histological lesions of the lungs were compatible with pulmonary adenocarcinoma. Lung adenocarcinoma in sheep is caused by jaagsiekte sheep retrovirus (JSRV) and originated from differentiated alveolar type II cells and non-ciliated bronchiolar epithelial Clara cells. We evidenced the expression of the oncogenic JSRV by immunostaining of lung slides with specific antibodies against the JSRV envelope. The viral proteins were expressed only in the tumor cells from the affected areas. As already described in other countries, JSRV-induced lung adenocarcinoma is present in the sheep population in Algeria.

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