Veterinary Research Forum
Vet Res Forum

Evaluation of effects of vancomycin/polycaprolactone nanocomposite in comparison with curcumin/polycaprolactone on the healing of experimental osteomyelitis in rabbit tibia

Document Type : Original Article

Authors

Amirreza Hajati Ziabari 1
Alireza Jahandideh 1
Abolfazl Akbarzadeh 2
Pejman Mortazavi 3

1 Department of Clinical Science, S.R.C., Islamic Azad University, Tehran, Iran

2 Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

3 Department of Pathobiology, S.R.C., Islamic Azad University, Tehran, Iran

https://doi.org/10.30466/vrf.2024.2028501.4268
Abstract
Osteomyelitis is caused by the local spread of an infected source adjacent to the infection following trauma, bone surgery or joint replacement. The present study aimed to evaluate the effect of vancomycin (Van)/polycaprolactone (PCL) nanocomposite in comparison with curcumin (Cur)/PCL on the healing of experimental osteomyelitis in tibia in rabbits. After induction of osteomyelitis forty adult male New Zealand white rabbits were randomly divided into four groups. Control group: The animals were considered as controls and no scaffolds were used. In PCL/Van group, the created bone defects were filled with the combination of PCL and Van. In PCL/Cur, the created bone defects were filled with the combination of PCL and Cur. Polycaprolactone/Cur/Van group: The created bone defects were filled with the combination of PCL, Cur and Van. Bone samples were taken for histopathological evaluation on the 30th and 60th days. For radiological evaluations of the osteomyelitis, radiographs were prepared at time intervals zero (day of surgery), 15, 30, 45, and 60 days after surgery. In order to evaluate hematology, blood was taken on days 0 (day of surgery), 15, 30, 45, and 60. The results of the present study showed that Cur nanocomposite significantly improved the healing process of the rabbit tibia experimental osteomyelitis model compared to the control group. Also, the PCL/Cur/Van group showed the best healing results. In conclusion, PCL/Cur/Van nanocomposite scaffold showed positive effects on the healing process.

Keywords

Curcumin
Nanocomposite
Osteomyelitis
Polycaprolactone
Vancomycin

Subjects

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Veterinary Research Forum
Volume 16, Issue 4
April 2025
Pages 235-243

  • Receive Date 08 May 2024
  • Revise Date 23 June 2024
  • Accept Date 29 July 2024

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