Veterinary Research Forum
Vet Res Forum

Effect of allogenic biomaterial on the development of adjuvant arthritis in mature female rats

Document Type : Short Communication

Authors

Musina Lyalya Akhiyarovna 1
Lebedeva Anna Ivanovna 1
Nazmutdinov Bulat Rinatovich 1
Prusakov Alexey Viktorovich 2
Yashin Anatoly Viktorovich 2
Ponamarev Vladimir Sergeevich 2

1 Russian Eye and Plastic Surgery Centre, Bashkir State Medical University, Ufa, Russia

2 Faculty of Veterinary Medicine, Saint Petersburg State University of Veterinary Medicine, Saint Petersburg, Russia

https://doi.org/10.30466/vrf.2025.2043931.4504
Abstract
The administration of dispersed allogeneic biomaterial (AB) into the para-articular region and joint cavity allows slowing down the processes of tissue destruction in arthritis. The aim of the study was to examine the effect of AB on the course of experimental adjuvant arthritis (AA) in rats. For modeling of AA, complete Freund's adjuvant was injected into the plantar surface of the hind paw of 60 white outbred female rats. The study included intact group, control group, and experimental group. After 37 days of the experiment, blood was collected for hematological analysis and the knee joint with surrounding tissues was harvested for standard histological examination. Intra-articular administration of AB to experimental rats while using complete Freund's adjuvant neutralized the manifestation of signs of a generalized inflammatory process in the joints and reduced the degree of destructive changes in the articular apparatus, preserving the structure of the cartilaginous layer. The use of AB made it possible to stabilize the red and white blood cells levels in the experimental group, as well as significantly increase the reduced level of monocytes. Intra-articular administration of AB during AA modeling exhibits an osteo- and chondro-protective effect, providing positive anti-inflammatory and symptom-modifying effects and weakening the manifestation of pathomorphological changes in the joints of experimental rats.

Keywords

Adjuvant arthritis
Allogeneic biomaterial
Chondroprotection
Osteoprotection
Rat

Subjects

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Veterinary Research Forum
Volume 16, Issue 10
October 2025
Pages 591-596

  • Receive Date 28 October 2024
  • Revise Date 15 March 2025
  • Accept Date 22 April 2025

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