Veterinary Research Forum
Vet Res Forum

Mammary comedocarcinoma in a rabbit

Document Type : Clinical Report

Authors

Ghasem Farjanikish 1
Saman Salmani 2
Mohammadhossein Abbasi 2
Mohammadreza Bayat 2
Erfan Vali 3

1 Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorram Abad, Iran

2 Department of Clinical Science, Faculty of Veterinary Medicine, Lorestan University, Khorram Abad, Iran

3 Department of Clinical Science, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran

https://doi.org/10.30466/vrf.2025.2049185.4610
Abstract
A 4.5-year-old, nulliparous female New Zealand White Rabbit (Oryctolagus cuniculus) was presented for evaluation of a mammary mass located in right axillary mammary gland. The surgically excised mammary mass was submitted for histopathological and immunohistochemical evaluation. Histopathologically, neoplastic cells were arranged in sheets and nests of irregular sizes. The tissue was composed of amorphous eosinophilic material and necrotic cells. The neoplastic cells had round to oval nuclei with prominent nucleoli, scant basophilic cytoplasm and high mitotic activity. Cytokeratin and vimentin expressions of neoplastic cells were observed in immunohistochemical findings. Based on the microscopic characteristics and immunohisto-chemical staining, a diagnosis of a non-invasive comedocarcinoma was established. In this case, cytokeratin positivity confirmed the epithelial origin, whereas the vimentin positivity supported the presence of epithelial-mesenchymal transition and/or increased malignancy.

Keywords

Comedocarcinoma
Mammary mass
Neoplastic cell
Rabbit

Subjects

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Veterinary Research Forum
Volume 16, Issue 12
December 2025
Pages 725-728

  • Receive Date 19 January 2025
  • Revise Date 19 April 2025
  • Accept Date 20 May 2025

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