Veterinary Research Forum
Vet Res Forum

Protein 53 expression in a mixed Labrador subcutaneous lymphoma

Document Type : Clinical Report

Authors

Annahita Rezaie 1
Abbas Tavassoli 2

1 Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2 Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Abstract
An 11 year – old mixed female Labrador was presented with two masses in trunk and neck. The tumoral masses were excised and sent for histopathological and immunohistochemical analyses. Histopathological examination of masses revealed diffuse infiltration of small sized lymphoid cells in subcutaneous tissue which were intense around the blood vessels. More than 10% lymphoid cells were CD3 positive in the immunohistochemical staining and most of them were accumulated around vessels. Protein 53 (p53) expression was detected by brown nuclei in immunohistochemical staining. Subcutaneous lymphoma was diagnosed according to histopathological results. After 6 months the case was referred with multicentric lymphoma and based on the owner request euthanasia was performed. These findings emphasize on poor prognosis for tumors with p53 mutation.

Keywords

Subcutaneous Lymphoma
Dog
p53
T cell
Immunohistochemistry

  • Receive Date 28 December 2012

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