Veterinary Research Forum
Vet Res Forum

The effect of cinnamaldehyde on the contractility of bovine isolated ‎gastrointestinal smooth muscle preparations

Document Type : Original Article

Authors

Alireza Arbati 1
Masoud Maham 2
Bahram Dalir-Naghadeh 2

1 DVSc Candidate, Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

2 Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

https://doi.org/10.30466/vrf.2020.112185.2670
Abstract
Gastrointestinal motility disorders can occur as either increased or decreased movements. Studies have shown that herbal ingredients such as essential oils can modify the increase and decrease of gastrointestinal movements of ruminants. Cinnamaldehyde at room temperature is an oily yellow liquid which is obtained from the steam distillation of the oil of cinnamon bark. It bears carminative activity and gastrointestinal, antimicrobial, and vasodilatory effects. This study examined the effects of cinnamaldehyde on the contraction of circular smooth muscles of abomasal fundus and the antrum, duodenum, and ileum of healthy cows using an in vitro approach. The results indicated that cinnamaldehyde had relaxant effects on the basal tonus and contractions caused by barium chloride (BaCl2) and carbachol (CCh) in these tissues dependent upon concentration and the origin of the smooth muscle. These effects were more prominent in the ileal smooth muscle preparations than in other tissues. This substance in the smooth muscle preparations of the abomasal fundus not only had no significant effect on the basal tonus, but also significantly increased the contractions caused by barium chloride at low concentrations. Study of the mechanism of action showed that, similar to verapamil, cinnamaldehyde applied its relaxation effect by blocking the calcium channels. The results showed that cinnamaldehyde possessed a spasmolytic effect mediated through blockage of the calcium channels, which may provide a pharmacological base to its medicinal use for diarrhea and spasms.

Keywords

Calcium channels
‎ Cinnamaldehyde
‎ Contraction
‎ Cow
‎ Smooth muscle
  1. Constable PD, Hinchclif KW, Done SH, et al. Veterinary medicine: A textbook of the diseases of cattle, horses, sheep, pigs and goats. 11th Pennsylvania, USA: Saunders 2017; 176-178.
  2. Fecteau G, Desrochers A, Francoz D, et al. Diagnostic approach to the acute abdomen. Vet Clin North Am Food Anim Pract 2018; 34(1):19-33.
  3. Navarre CB, Roussel AJ. Gastrointestinal motility and disease in large animals. J Vet Intern Med 1996; 10 (2): 51-59.
  4. Heller MC, Chigerwe M. Diagnosis and treatment of infectious enteritis in neonatal and juvenile ruminants. Vet Clin North Am Food Anim Pract 2018; 34(1):101-117.
  5. Ugbogu EA, Elghandour MMMY, Ikpeazu VO, et al. The potential impacts of dietary plant natural products on the sustainable mitigation of methane emission from livestock farming. J Clean Prod 2019; 213: 915-925.
  6. Mendel M, Chłopecka M, Dziekan N, et al. Phytogenic feed additives as potential gut contractility modifiers-A review. Anim Feed Sci Technol 2017; 230: 30-46.
  7. Brenes A, Roura E. Essential oils in poultry nutrition: Main effects and modes of action. Anim Feed Sci Technol 2010; 158(1-2): 1-14.
  8. Burnham PM. Molecule of the month. Cinnamaldehyde, The smell and flavour of cinnamon. Available at: http://www.chm.bris.ac.uk/motm/cinnamaldehyde/cinnh.htm. Accessed July 10, 2021.
  9. Wynn S, Fougere B. Veterinary herbal medicine. 1st Philadelphia, USA: Mosby 2006; 513-514.
  10. Harada M, Yano S. Pharmacological studies on Chinese cinnamon. II. Effects of cinnamaldehyde on the cardiovascular and digestive systems. Chem Pharm Bull (Tokyo) 1975; 23(5):941-947.
  11. Friedman M. Chemistry, antimicrobial mechanisms, and antibiotic activities of cinnamaldehyde against pathogenic bacteria in animal feeds and human foods. J Agric Food Chem 2017; 65(48): 10406-10423.
  12. Hong S-H, Ismail IA, Kang S-M, et al. Cinnamaldehydes in cancer chemotherapy. Phytother Res 2016; 30(5): 754-767.
  13. Chaves AV, Stanford K, Dugan MER, et al. Effects of cinnamaldehyde, garlic and juniper berry essential oils on rumen fermentation, blood metabolites, growth performance, and carcass characteristics of growing lambs. Livest Sci 2008; 117(2-3): 215-224.
  14. Babu PS, Prabuseenivasan S, Ignacimuthu S. Cinnamaldehyde--a potential antidiabetic agent. Phytomedicine 2007; 14(1):15-22.
  15. Cardozo PW, Calsamiglia S, Ferret A, et al. Effects of alfalfa extract, anise, capsicum, and a mixture of cinnamaldehyde and a eugenol on ruminal fermentation and protein degradation in beef heifers fed a high-concentrate diet. J Anim Sci 2006; 84 (10):2801-2808.
  16. Farre AJ, Colombo M, Fort M, et al. Differential effects of various Ca2+ Gen Pharmacol 1991; 22(1): 177-181.
  17. Raffai G, Kim B, Park S, et al. Cinnamaldehyde and cinnamaldehyde-containing micelles induce relaxation of isolated porcine coronary arteries: role of nitric oxide and calcium. Int J Nanomedicine 2014; 9: 2557-2566.
  18. Xue YL, Shi HX, Murad F, et al. Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta. Vasc Health Risk Manag 2011; 7: 273-280.
  19. Alotaibi M. The effect of cinnamon extract on isolated rat uterine strips. Reprod Biol 2016; 16(1): 27-33.
  20. Jalilzadeh-Amin G, Maham M, Dalir-Naghadeh B, et al. Effects of bunium persicum (Boiss.) essential oil on the contractile responses of smooth muscle (an in vitro study). Vet Res Forum 2011; 2(2): 87-96.
  21. Yu J, Bose R. Calcium channels in smooth muscle. Gastroenterology 1991; 100(5 Pt 1):1448-1460.
  22. Lyford GL, Farrugia G. Ion channels in gastrointestinal smooth muscle and interstitial cells of Cajal. Curr Opin Pharmacol 2003; 3(6):583-587.
  23. Evans ED, Mangel AW. Depolarization-stimulated contractility of gastrointestinal smooth muscle in calcium-free solution. ISRN Gastroenterol 2011; 2011: 692528. doi: 10.5402/2011/692528.
Veterinary Research Forum
Volume 12, Issue 3
Summer 2021
Pages 313-318

  • Receive Date 30 July 2019
  • Revise Date 14 December 2019
  • Accept Date 08 January 2020

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