Document Type : Clinical Report


1 Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

2 Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran

3 Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran

4 Department of Clinical Sciences, College of Veterinary Medicine, Karaj Branch, Islamic Azad University, Alborz, Iran


A 10-year-old, male Rottweilerdog was presented to Small Animal Hospital of Tehran University with a history of lethargy, anorexia, weight loss, vomiting, polyuria, polydipsia and blindness. The dog showed symptoms of depression, high body temperature (39.2 ˚C), tachypnea (40 breaths min-1) and cachexia. In ophthalmic examination, bilateral hyphema (hemmorrahge in anterior chamber of the eye) and blindness were detected. The pulse of the animal was normal (90 beats min-1) and obvious general lymphadenopathy was determined. Lymph nodes were firm, freely movable, and painless on palpation. Initial differential diagnosis of lymphoma included lymphoma, metastatic neoplasia, lymphoid hyperplasia, and lymphadenitis. In hematology and cytology tests, this case was suspected to lymphoma. Immunohistochemical staining of neoplastic lymph node revealed that nearly 20.00 – 25.00% of neoplastic cells were strongly positive for anti CD3, whereas they were negative for both CD20 and CD79a. According to the microscopic and immunohistochemical findings, a diagnosis of T cell lymphoma was made. The present report is the first case of multicentric lymphoma with ocular metastasis in a dog in Iran.


Main Subjects


    1. Rallis T, Koutinas A, Lekkas S, et al. Lymphoma (malignant lymphoma, lymphosarcoma) in the dog. J Small Anim Pract. 1992; 33(12): 590-596.
    2. Vail DM, MacEwen EG, Young KM. Canine lymphoma and lymphoid leukemias. In: Withrow SJ, MacEwen EG (Eds). Small animal clinical oncology. 3rd ed. Philadelphia, USA: WB Saunders 2001; 558-580.
    3. Sequeira JL, Franco M, Bandarra EP, et al. Anatomoclinical characteristics of canine lymphomas in the region of Botucatu, São Paulo [Portuguese]. Arq Bras Med Vet Zootec 1999; 51(3): 245- 250.
    4. Nelson RW, Couto CG. Small animal internal medicine. 2nd ed. St. Louis, USA: Mosby 1998; 1123-1133.
    5. Starrak GS, Berry CR, Page RL, et al. Correlation between thoracic changes and remission/survival duration in 270 dogs with lymphosarcoma. Vet Radiol Utrasound. 1997; 38(6): 411-418.
    6. Teske E, Heerde PV, Rutteman GR, et al. Prognostic factors for treatment of malignant lymphoma in dogs. J Am Vet Med Assoc. 1994; 205(12): 1722-1728.
    7. Milner RJ, Pearson J, Nesbit JW, et al. Immuno-phenotypic classification of canine malignant lymphoma on formalin-fixed paraffin wax-embedded tissue by means of CD3 and CD79a cell markers. J Vet Res 1996; 63(4): 309-313.
    8. Fournel-Fleury C, Ponce F, Felman P, et al. Canine T-cell lymphomas: A morphological, immunological, and clinical study of 46 new cases. Vet Pathol 2002; 39(1): 92-109.
    9. Hosoya K, Kisseberth WC, Lord LK, et al. Comparison of COAP and UW‐19 protocols for dogs with multicentric lymphoma. J Vet Intern Med. 2007; 21(6): 1355-1363.
    10. Nelson RW, Couto CG. Small animal internal medicine 5th ed. St. Louis, USA: Mosby 2013; 1160-1174.