Veterinary Research Forum
Vet Res Forum

Ameliorative properties of aqueous extract of Ficus thonningii on erythrocyte osmotic fragility induced by acetaminophen in Rattus norvegicus

Document Type : Original Article

Authors

Victor Masekaven Ahur 1
Yahaya Adenkola Adenkola 1
Saganuwan Alhaji Saganuwan 1
Job Terungwa Ikye-Tor 2

1 Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Agriculture, Makurdi, Nigeria

2 Division of Livestock Services, Benue State Ministry of Agriculture and Natural Resources, Makurdi, Nigeria

Abstract
In vitro antioxidant and erythrocyte protecting activities by aqueous extract of Ficus thonningii leaves on blood cells were studied in acetaminophen treated rats. The extract was safe at limit dose of 5000 mg kg-1body weight. The extract demonstrated dose dependent antihemolytic effect at dose levels between 50 and 200 mg kg-1 body weight. The lowest antihemolytic effect was observed at dose level of 200 mg kg-1 body given the lowest percentage hemolysis of 10.53 ± 1.76%, whereas the highest percentage hemolysis at dose level of 50 mg kg-1 was 29.02 ± 7.45%. Hematology revealed erythrocytosis at dose levels of 100 and 200 mg kg-1 body weight. Hyper-globinemia and lymphocytopenia were observed at dose levels of 100 mg kg-1 and 200 mg kg-1, respectively. The extract effectively showed scavenging activity on a stable oxidative radical diphenylpicrylhydrazyl (DPPH) and a significant ferric reducing antioxidant power (FRAP) activity. The plausible erythrocyte membrane protective effect may be due to its free radical scavenging activity and hence the extract can be used to improve hematological parameters and ameliorate oxidative stress.

Keywords

Acetaminophen
Erythrocytes
Ficus thonningii
osmotic fragility
Veterinary Research Forum
Volume 4, Issue 4 - Serial Number 4
December 2013
Pages 207-212

  • Receive Date 01 October 2012
  • Accept Date 02 March 2013

Home

Guide for Authors

Submit Manuscript

Reviewers

Contact Us