Document Type : Clinical Report
Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Canine lymphoma is the most common neoplasm of the hematopoietic system with the most frequently diagnosed malignancy. Also, dogs affected by T-cell lymphoma displayed a lower rate of complete chemotherapy response and have a high risk of death in the early stage of the disease. A 5-year-old male mixed dog was presented to the Small Animal Hospital, School of Veterinary Medicine, Shiraz University, Shiraz, Iran with a history of left testicle swelling for four months. The testicle had approximately 13.00×10.00 cm size with a greyish-white cut surface. Histopathologically, the testicular tissue was infiltrated by neoplastic cells as only a few degenerated seminiferous tubules have remained. The neoplastic cells were round to oval with pleomorphic nuclei and single or multiple prominent nucleoli. Immunohistochemical analysis revealed positive and negative immunoreactivity for CD3 and CD20, respectively. According to histopathological and immunohistochemical features, the tumor was concluded as a testicular T-cell lymphoma. It seems that recognition of lymphoma type could be helpful for clinicians therapeutic protocols.
- Spugnini EP, Bartolazzi A, Ruslander D. Seminoma with cutaneous metastases in a dog. J Am Anim Hosp Assoc 2000; 36(3): 253-256.
- Zandvliet M. Canine lymphoma: A review. Vet Quart 2016; 36(2): 76-104.
- Vail DM, MacEwen EG, Young KM. Canine lymphoma and lymphoid leukemias. In: Withrow SJ, MacEwen EG (Eds). Small animal clinical oncology. 3rd ed. Philadelphia, USA: WB Saunders 2001; 558-580.
- Rungsipipat A, Chayapong J, Jongchalermchai J, et al. Histopathological classification and immunophenotyping of spontaneous canine lymphoma in Bangkok metropolitan. Comp Clin Path 2014; 23: 213-222.
- Arespacochaga AG, Schwendenwein I, Weissenbock H. Retrospective study of 82 cases of canine lymphoma in Austria based on working formulation and immunophenotyping. J Comp Pathol 2007; 136: 186-192.
- Ponce F, Marchal T, Magnol JP, et al. A morphological study of 608 cases of canine malignant lymphoma in France with a focus on comparative similarities between canine and human lymphoma morphology. Vet Pathol 2010; 47(3): 414-433.
- Fan TM. Lymphoma updates. Vet Clin North Am Small 2003; 33(3): 455-471.
- Sueiro FA, Alessi AC, Vassallo J. Canine lymphomas: A morphological and immunohistochemical study of 55 cases, with observations on p53 immunoexpression. J Comp Pathol 2004; 131: 207-213.
- Teske E. Canine malignant lymphoma: A review and comparison with human non-Hodgkin’s lymphoma. Vet Quart 1994;16(4): 209-219.
- Neuwald EB, Teixeira LV, Conrado FO, et al. Epidemiological, clinical and immunohistochemical aspects of canine lymphoma in the region of Porto Alegre, Brazil. Braz J Vet Res Anim Sci 2014; 34(4): 349-354.
- Moreno K, Bracarense APFRL. Canine T-cell lymphoma: Epidemiological, clinical and morphological aspects of 38 cases [Spanish]. Braz J Vet Res Anim Sci 2007; 44(S): 103-110.
- Valli VE, Kass PH, San Myint M, et al. Canine lymphomas: Association of classification type, disease stage, tumor subtype, mitotic rate, and treatment with survival. Vet Pathol 2013; 50(5): 738-748.
- Moore AS. Treatment of T cell lymphoma in dogs. Vet Rec 2016; 179: 277-281.
- Dolka I, Gruk-Jurka A, Wojtkowska A, et al. Evaluation of canine mammary tumors using cytologic features, computerized cytomorphometry and immunocytochemistry. J Comp Pathol 2016; 154(1): 110. doi:10.1016/j.jcpa.2015.10.132.
- Cora R, Gal AF, Taulescu M, et al. Immunohistochemical characterization of canine lymphomas. Bull Univ Agric Sci Vet Med 2017; 74(2): 149-155. doi: 10.15835/buasvmcn-vm:0003.