Document Type : Clinical Report

Authors

1 DVSc Graduate, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

2 Private Veterinary Practitioner, Tehran, Iran

3 Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

4 Ex FAO International Laboratory Specialist, Tehran, Iran

5 Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

6 Department of Microbiology and Immunology, Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Karaj, Iran

7 Molecular Department, Mabna Veterinary Laboratory, Karaj, Iran

Abstract

Mycoplasma capricolum subspecies capripneumoniae (Mccp) is the etiological agent of caprine contagious pleuropneumonia (CCPP) disease. The CCPP is one of the most severe diseases of goats. A herd of 2,000 goats located in the countryside of Tehran city, Iran, was examined for the study in August 2021. In history taking, observation, inspection and clinical examination, high case fatality rate (46.00%) due to respiratory distress and high morbidity of pleuropneumonia (15.00%) syndrome were recorded. Accordingly, ten carcasses of goats were dissected. The epidemiological pattern of the disease, clinical examination findings and the signs of necropsy of dead patients were suspected to CCPP. Four lung samples of necropsied goats were sent to the laboratory for PCR test and in all of them, Mccp was detected and CCPP was also confirmed. The disease was controlled by two measures: (a) the whole herd was first treated with antibiotics (florfenicol and tylosin) and (b) then the Pulmovac-In vaccine was then administered. This study is the first documented report of CCPP occurrence caused by Mccp in Iran and shows the importance of availability of effective vaccines to control and prevention of CCPP.

Keywords

  1. Constable PD, Hinchcliff KW, Done SH, et al. Veterinary medicine. 11th Philadelphia, USA: Saunders Elsevier 2016; 970-972.
  2. Nicholas RAJ, Ayling RD, McAuliffe L. Mycoplasma diseases of ruminants. 1st Surrey, UK: CAB International 2008; 98-113.
  3. Thiaucourt F, Bölske G. Contagious caprine pleuro-pneumonia and other pulmonary mycoplasmoses of sheep and goats. Rev Sci Tech 1996; 15(4): 1397-1414.
  4. Iqbal Yatoo M, Raffiq Parray O, Tauseef Bashir S, et al. Contagious caprine pleuropneumonia - a comprehensive review. Vet Q 2019; 39(1): 1-25.
  5. Namazi F, Derakhshandeh A, Sajadi Hezaveh S, et al. Detection of Mycoplasma capricolum subsp. capri-pneumoniae and Mannheimia haemolytica as causative agents of pleuropneumonia in goats. Revista Infectio 2020; 24(4): 208-211.
  6. Woubit S, Lorenzon S, Peyraud A, et al. A specific PCR for the identification of Mycoplasma capricolum subsp. capripneumoniae, the causative agent of contagious caprine pleuropneumonia (CCPP). Vet Microbiol 2004; 104(1-2): 125-132.
  7. Nicholas R, Churchward C. Contagious caprine pleuro-pneumonia: new aspects of an old disease. Transbound Emerg Dis 2012; 59(3): 189-196.
  8. Teshome D, Sori T. Contagious caprine pleuro-pneumonia: A review. J Vet Med Anim Health 2021; 13(3): 132-143.
  9. Parray OR, Yatoo MI, Muheet, et al. Seroepidemiology and risk factor analysis of contagious caprine pleuro- pneumonia in Himalayan Pashmina Goats. Small Rumin Res 2019; 171: 23-36.
  10. Wesonga HO, Bölske G, Thiaucourt F, et Experimental contagious caprine pleuropneumonia: a long term study on the course of infection and pathology in a flock of goats infected with Mycoplasma capricolum subsp. capripneumoniae. Acta Vet Scand 2004; 45(3-4): 167-179.
  11. Sadique U, Chaudhry ZI, Younus M, et al. Clinico-pathological study of contagious caprine pleuro-pneumonia (CCPP) in small ruminants. J Anim Plant Sci 2012; 22(2 Suppl.): 45-50.
  12. Iqbal Yatoo M, Rafiq Parray O, Mir MS, et al. Myco-plasmosis in small ruminants in India: a review. J Exp Biol Agric Sci 2018; 6(2): 264-281.
  13. Ping Z, Ying H, Yuefeng C, et al. Development of contagious caprine pleuropneumonia inactivated vaccine (M1601 strain). Anim Husb Feed Sci 2014; 6(5): 276-278.