Veterinary Research Forum
Vet Res Forum

Effects of intracerebroventricular injection of apelin-13 on food intake in broiler chicks

Document Type : Short Communication

Authors

Razieh Amini Zadeh 1
Hossein Jonaidi 1
Saeed Esmaeili-Mahani 2
Mahsa Salehi 1
Mojtaba Emam Bakhsh 1

1 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran

2 Department of Biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman, Kerman, Iran

https://doi.org/10.30466/vrf.2022.545646.3335
Abstract
Apelin is an endogenous peptide ligand for G protein coupled apelin receptors (APJ orphan receptors) which are very similar to angiotensin II receptors. Apelin is expressed in most tissues of the body including hypothalamus that is responsible for regulating water and food intake, the gastrointestinal tract, the circulatory system, adipose and muscle tissues, and the immune system. The physiological actions of apelin, including food intake, has not yet been reported in birds. In this study, the effect of intracerebroventricular injection of different doses of apelin-13 was investigated on food intake in neonatal broilers at the age of five and seven days. The chicks had access to food immediately after injection and cumulative food intake was measured at half, 1, 2, 3, 4, 8 and 21 hr after injection. The 2-way ANOVA analyzed data showed that apelin-13 at dose of 1.00 μg significantly reduced food intake at 21 hr after injection in five-day old chicks. In addition, in dose of 1.50 μg, it could significantly reduce food intake at 2, 3, 4, 8 and 21 hr after injection. In seven-day-old chicks, the doses of 1.00 and 4.00 μg of apelin-13 had no effect on food intake compared to the control group. Apelin-13 at dose of 2.00 μg significantly reduced food intake at 8 and 21 hr after injection. The results of this study showed that apelin-13 had a reducing effect on food consumption in neonatal broiler chicks.

Keywords

Apelinergic system
Broilers
Intracerebroventricular injection
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Veterinary Research Forum
Volume 14, Issue 2
February 2023
Pages 105-108

  • Receive Date 27 December 2021
  • Revise Date 11 March 2022
  • Accept Date 18 May 2022

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