Document Type : Clinical Report


Department of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan


Acute pulmonary edema in puppies generally occurs due to congenital left-right shunts such as patent ductus arteriosus or large ventricular septal defects. Herein, we presented two cases of puppies with no apparent congenital cardiovascular disease. Case 1: A 12-day-old male Labrador Retriever, weighing 1.15 kg, was unable to suckle sufficiently from its dam and exhibited laboured breathing. Pulmonary edema was identified in all lung lobes by radiography, furthermore, echocardiography revealed significant enlargement of the left side of the heart. Pulmonary edema secondary to volume overload was suspected and furosemide was administered. The respiratory status was improved on the following day. Pimobendan was administered orally in addition to furosemide and both were withdrawn 6 weeks later when the heart size was normalized. Case 2: A 15-day-old female Standard Poodle, weighing 0.68 kg, was less active than other littermates and exhibited laboured breathing. Radiography revealed pulmonary edema in the right posterior lobe, dilatation of the caudal vena cava and ascites. Echocardiography revealed significant enlargement of the left atrium and ventricle perhaps owing to decreased left ventricular contractility. Furosemide and pimobendan were administered. One week later, appetite was improved and supraventricular tachycardia of 375 bpm was observed. Therefore, tachycardia-induced dilated cardiomyopathy was suspected which returned to sinus rhythm with diltiazem treatment, however, it was recurred. Upon sotalol monotherapy, a normal heart size was observed seven months later. In conclusion, we encountered two new-born puppies with transient pulmonary edema that were temporarily treated with pimobendan and furosemide.


  1. Hayes MA, Russell RG, Babiuk LA. Sudden death in young dogs with myocarditis caused by parvovirus. J Am Vet Med Assoc 1979; 174(11): 1197-1203.
  2. Sleeper MM, Henthorn PS, Vijayasarathy C, et al. Dilated cardiomyopathy in juvenile Portuguese water dogs. J Vet Intern Med 2002; 16(1): 52-62.
  3. Vollmar A, Fox PR, Meurs KM, et al. Dilated cardiomyo-pathy in juvenile Doberman Pinschers. J Vet Cardiol 2003; 5(1): 23-27.
  4. Jetton JG, Boohaker LJ, Sethi SK, et al. Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study. Lancet Child Adolesc Health 2017; 1(3): 184-194.
  5. Talner NS. Congestive heart failure in the infant. A functional approach. Pediatr Clin North Am 1971; 18(4): 1011-1029.
  6. Wright KN, Connor CE, Irvin HM, et al. Atrioventricular accessory pathways in 89 dogs: Clinical features and outcome after radiofrequency catheter ablation. J Vet Intern Med 2018; 32(5): 1517-1529.
  7. Lee PM, Brown RHT. Establishing 24-hour Holter reference intervals for clinically healthy puppies. Res Vet Sci2019; 125: 253-255.
  8. Guglielmini C, Goncalves Sousa M, Baron Toaldo M, et al. Prevalence and risk factors for atrial fibrillation in dogs with myxomatous mitral valve disease. J Vet Intern Med 2020; 34(6): 2223-2231.
  9. Cornell CC, Kittleson MD, Torre P, et al. Allometric scaling of M-mode cardiac measurements in normal adult dogs. J Vet Intern Med 2004; 18(3): 311-321.
  10. Bayón A, del Palacio MJF, Montes AM et al. M-mode echocardiography study in growing Spanish mastiffs. J Small Anim Pract 1994; 35(9): 473-479.