Veterinary Research Forum
Vet Res Forum

Impact of dietary curcumin administration along with feed-born silver nanoparticle on growth, hemato-biochemical parameters, and digestive enzyme activity of common carp (Cyprinus carpio)

Document Type : Original Article

Authors

Zohre Khorshidi 1
Kourosh Sarvi Moghanlou 1
Ahmad Imani 1
Shahryar Behrouzi 2

1 Department of Fisheries, Faculty of Natural Resources, Urmia University, Urmia, Iran

2 Department of Comparative Histology, Ecology Institute of Caspian Sea, Sari, Iran

https://doi.org/10.30466/vrf.2023.1982714.3708
Abstract
This research explored the impacts of feed-born silver nanoparticles (AgNPs) on common carp (Cyprinus carpio) and whether dietary curcumin supplementation could ameliorate the impacts of AgNPs on growth, hemato-biochemical parameters and digestive enzyme activity. Nine experimental diets were prepared containing 0.00, 0.05, and 0.15 g kg-1 AgNPs, as well as 0.00, 0.75, and 1.50 g kg-1 curcumin in a factorial design. Triplicate groups of common carp (4.82 ± 0.41 g) were fed on the test diets for 60 days. The results demonstrated that AgNPs reduced growth performance and enhanced the feed conversion ratio dose-dependently. Supplementing 0.75 g kg-1 curcumin at a low AgNP level improved the growth rate, while its inclusion at a high AgNP level led to further suppression of growth performance. The highest hematocrit value, hemoglobin concentration and white blood cell count were recorded in the group receiving 0.75 g kg-1 curcumin. Serum glucose, cholesterol and triglyceride concentrations were elevated by increasing AgNP levels. However, curcumin inclusion, particularly at the lower level of AgNPs significantly decreased their values. Similarly, intestinal alkaline protease and lipase activities were progressively reduced by increasing dietary AgNP contents, but, significant improvements were observed by curcumin application at the lower AgNP level. Our results revealed that curcumin supplementation could limit the toxic effects of lower dietary AgNP contents.

Keywords

Curcumin
Cyprinus carpio
Performance
Silver nanoparticles

Subjects

  1. Bhatt I, Tripathi BN. Interaction of engineered nanoparticles with various components of the environment and possible strategies for their risk Chemosphere 2011; 82(3): 308-317.
  2. Luoma SN. Silver nanotechnologies and the environment. Old problems or new challenges? PEN 2008; 15: 12-13.
  3. Reed RB, Zaikova T, Barber A, et al. Potential environmental impacts and antimicrobial efficacy of silver-and nanosilver-containing textiles. Environ Sci Technol 2016; 50(7): 4018-4026.
  4. Federici G, Shaw BJ, Handy RD. Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): Gill injury, oxidative stress, and other physio-logical effects. Aquat Toxicol 2007; 84(4): 415-430.
  5. Handy RD, von der Kammer F, Lead JR, et al. The ecotoxicology and chemistry of manufactured nanoparticles. Ecotoxicology 2008; 17(4): 287-314.
  6. Chen PJ, Wu WL, Wu KC. The zerovalent iron nano-particle causes higher developmental toxicity than its oxidation products in early life stages of medaka fish. Water Res 2013; 47(12): 3899-3909.
  7. Agarwal M, Murugan M, Sharma A, et al. Nanoparticles and its toxic effects: A Review. Int J Curr Microbiol App Sci 2013; 2(10): 76-82.
  8. Doronicheva N, Yasui H, Sakurai H. Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method. Biol Pharm Bull 2007; 30(2): 213-217.
  9. Souza MF, Tomé AR, Rao VSN. Inhibition by the bioflavonoid ternatin of aflatoxin B1 -induced lipid peroxidation in rat liver. J Pharm Pharmacol 1999; 51(2): 125-129.
  10. Sahoo PK, Mukherjee SC. Influence of high dietary α-tocopherol intakes on specific immune response, nonspecific resistance factors and disease resistance of healthy and aflatoxin B1-induced immuno-compromised Indian major carp, Labeo rohita (Hamilton). Aquac Nutr 2002; 8(3): 159-167.
  11. Ciardi C, Jenny M, Tschoner A, et al. Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro. Br J Nutr 2012; 107(6): 826-833.
  12. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med 2003; 9(1): 161-168.
  13. Jayaprakasha GK, Rao LJ, Sakariah KK. Antioxidant activities of curcumin, demethoxycurcumin and bisde-methoxycurcumin. Food Chem 2006; 98(4): 720-724.
  14. Swamy MV, Citineni B, Patlolla JM, et al. Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids. Nutr Cancer 2008; 60(Suppl 1): 81-89.
  15. Mishra S, Narain U, Mishra R, et al. Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties. Bioorg Med Chem 2005; 13(5): 1477-1486.
  16. Liang G, Yang S, Jiang L, et al. Synthesis and anti-bacterial properties of mono-carbonyl analogues of curcumin. Chem Pharm Bull (Tokyo) 2008; 56(2): 162-167.
  17. Manju M, Sherin TG, Rajasekharan KN, et al. Curcumin analogue inhibits lipid peroxidation in a freshwater teleost, Anabas testudineus (Bloch) - - an in vitro and in vivo study. Fish Physiol Biochem 2009; 35(3): 413-420.
  18. Khorshidi Z, Sarvi Moghanlou K, Imani A, et al. The interactive effect of dietary curcumin and silver nanoparticles on gut microbiota of common carp (Cyprinus carpio). Iran J Sci Technol Trans Sci 2018; 42: 379-387.
  19. Yonar ME, Mişe Yonar S, İspir Ü, et al. Effects of curcumin on haematological values, immunity, antioxidant status and resistance of rainbow trout (Oncorhynchus mykiss) against Aeromonas salmonicida achromogenes. Fish Shellfish Immunol 2019; 89: 83-90.
  20. Mahmoud HK, Al-Sagheer AA, Reda FM, et al. Dietary curcumin supplement influence on growth, immunity, antioxidant status, and resistance to Aeromonas hydrophila in Oreochromis niloticus. Aquaculture 2017; 475: 16-23.
  21. Alagawany M, Farag MR, Abdelnour SA, et al. Curcumin and its different forms: A review on fish nutrition. Aquaculture 2021; 532: 736030. doi: 10.1016/ j.aquaculture.2020.736030
  22. Golestan G, Salati AP, Keyvanshokooh S, et al. Effect of dietary aloe vera on growth and lipid peroxidation indices in rainbow trout (Oncorhynchus mykiss). Vet Res Forum 2015; 6(1): 63-67.
  23. Imani M, Halimi M, Khara H. Effects of silver nanoparticles (AgNPs) on hematological parameters of rainbow trout, Oncorhynchus mykiss. Comp Clin Pathol 2015; 24: 491-495.
  24. Keiding R, Hörder M, Denmark WG, et al. Recommended methods for the determination of four enzymes in blood. Scand J Clin Lab Invest 1974; 33(4): 291-306.
  25. Chong ASC, Hashim R, Chow-Yang L, et al. Partial characterization and activities of proteases from the digestive tract of discus fish (Symphysodon aequifasciata). Aquaculture 2002; 203(3-4): 321-333.
  26. Métais P, Bieth J. Determination of alpha-amylase by a microtechnique [French]. Ann Biol Clin (Paris) 1968; 26(1): 133-142.
  27. Iijima N, Tanaka S, Ota Y. Purification and characterization of bile salt-activated lipase from the hepatopancreas of red sea bream, Pagrus major. Fish Physiol Biochem 1998; 18: 59-69.
  28. Seebaugh DR, L’Amoreaux WJ, Wallace WG. Digestive toxicity in grass shrimp collected along an impact gradient. Aquat Toxicol 2011; 105(3-4): 609-617.
  29. Lee KW, Everts H, Kappert HJ, et al. Effects of dietary essential oil components on growth performance, digestive enzymes and lipid metabolism in female broiler chickens. Br Poult Sci 2003; 44(3): 450–457.
  30. Imani A, Salimi Bani M, Noori F, et al. The effect of bentonite and yeast cell wall along with cinnamon oil on aflatoxicosis in rainbow trout (Oncorhynchus mykiss): Digestive enzymes, growth indices, nutritional performance and proximate body composition. Aquaculture 2017; 476: 160-167.
  31. Ali H, Tripathi G. Assessment of toxicity of silver nanoparticles in an air-breathing freshwater catfish, Clarias batrachus. J Exp Zool India 2014; 17(01): 151-154.
  32. Wang T, Long X, Cheng Y, et al. A comparison effect of copper nanoparticles versus copper sulphate on juvenile Epinephelus coioides: Growth parameters, digestive enzymes, body composition, and histology as biomarkers. Int J Genomics 2015; 783021. doi: 10.1155/2015/783021.
  33. Ramsden CS, Smith TJ, Shaw BJ, et al. Dietary exposure to titanium dioxide nanoparticles in rainbow trout, (Oncorhynchus mykiss): no effect on growth, but subtle biochemical disturbances in the brain. Ecotoxicology 2009; 18(7): 939-951.
  34. Shaluei F, Hedayati A, Jahanbakhshi A, et al. Effect of subacute exposure to silver nanoparticle on some hematological and plasma biochemical indices in silver carp (Hypophthalmichthys molitrix). Hum Exp Toxicol 2013; 32(12): 1270-1277.
  35. Laban G, Nies LF, Turco RF, et al. The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos. Ecotoxicology 2010; 19(1): 185-195.
  36. Lavanya S, Ramesh M, Kavitha C, et al. Hematological, biochemical and ionoregulatory responses of Indian major carp Catla catla during chronic sublethal exposure to inorganic arsenic. Chemosphere 2011; 82(7): 977-985.
  37. Fırat O, Cogun HY, Yüzereroğlu TA, et al. A comparative study on the effects of a pesticide (cypermethrin) and two metals (copper, lead) to serum biochemistry of Nile tilapia, Oreochromis niloticus. Fish Physiol Biochem 2011; 37(3): 657-666.
  38. Masouleh FF, Amiri, BM, Mirvaghefi A, et al. Silver nanoparticles cause osmoregulatory impairment and oxidative stress in Caspian kutum (Rutilus kutum, Kamensky 1901). Environ Monit Assess 2017; 189(9): 448. doi: 10.1007/s10661-017-6156-3.
  39. Kumar N, Krishnani KK, Kumar P, et al. Dietary nano-silver: Does support or discourage thermal tolerance and biochemical status in air-breathing fish reared under multiple stressors? J Therm Biol 2018; 77: 111-121.
  40. Kumar N, Krishnani KK, Gupta SK, et al. Effects of silver nanoparticles on stress biomarkers of Channa striatus: immuno-protective or toxic? Environ Sci Pollut Res Int 2018; 25(15): 14813-14826.
  41. Sunde J, Taranger GL, Rungruangsak-Torrissen K. Digestive protease activities and free amino acids in white muscle as indicators for feed conversion efficiency and growth rate in Atlantic salmon (Salmo salar). Fish Physiol Biochem 2001; 25: 335-345.
  42. Le Bihan E, Perrin A, Koueta N. Development of a bioassay from isolated digestive gland cells of the cuttlefish Sepia officinalis (Mollusca Cephalopoda): effect of Cu, Zn and Ag on enzyme activities and cell viability. J Exp Mar Bio Ecol 2004; 309(1): 47-66.
  43. Samanta P, Pal S, Mukherjee AK, et al. Effects of almix herbicide on profile of digestive enzymes of three freshwater teleostean fishes in rice field condition. Toxicol Rep 2014; 1: 379-384.
  44. Tasa H, Imani A, Sarvi Moghanlou K, et al. Aflatoxicosis in fingerling common carp (Cyprinus carpio) and protective effect of rosemary and thyme powder: Growth performance and digestive status. Aquaculture 2020; 527: 735437. doi: 10.1016/j.aquaculture. 2020.735437.
  45. Nazdar N, Imani A, Noori F, et al. Effect of silymarin supplementation on nickel oxide nanoparticle toxicity to rainbow trout (Oncorhynchus mykiss) Fingerlings: Pancreas tissue histopathology and alkaline protease activity. Iran J Sci Technol Trans Sci 2018; 42(2): 353-361.
Veterinary Research Forum
Volume 14, Issue 10
October 2023
Pages 567-573

  • Receive Date 14 December 2022
  • Revise Date 14 March 2023
  • Accept Date 09 January 2023

Home

Guide for Authors

Submit Manuscript

Reviewers

Contact Us