Document Type : Original Article
Authors
1 Department of Fisheries, Faculty of Natural Resources, Urmia University, Urmia, Iran
2 Urmia University, Faculty of Natural Resources, Department of Fisheries
3 Urmia University
4 Department of Comparative Histology, Ecology Institute of Caspian Sea, Sari, Iran
Abstract
The rapid development and application of nano-materials are coupled with environmental hazards. The effect of feed-born silver nanoparticles (AgNPs) and the protective efficacy of dietary Curcumin supplementation were investigated. To this end, nine experimental diets were prepared to contain 0, 0.05, and 0.15 g.kg feed-1 AgNPs, as well as 0, 0.75, and 1.5 g.kg feed-1 Curcumin in a factorial design. Triplicate groups of common carp (4.82 ± 0.41 g) were fed the test diets for 60 days. The results showed AgNPs reduce growth performance and enhance the feed conversion ratio dose-dependently (P<0.05). In addition, supplementing 0.75 g.kg feed-1 Curcumin at a low AgNP level improved the growth rate (P<0.05), while its inclusion at a high AgNP level led to further suppression of growth performance. The highest hematocrit value, hemoglobin concentration, and white blood cell count were recorded in those fish received 0.75 g.kg feed-1 Curcumin, indicating the positive effect of dietary Curcumin supplementation on fish hematological indices. Based on the results, serum glucose, cholesterol, and triglyceride concentrations were enhanced by increasing AgNP levels (P<0.05). However, Curcumin inclusion, particularly at the lower level of AgNPs, significantly decreased their values (P<0.05). Similarly, intestinal alkaline protease and lipase activities were progressively decreased by increasing dietary AgNP contents revealing the pathological effect of AgNP on nutrient digestion and consequently absorption capability of fish intestine; however, significant improvements were found by Curcumin application at the lower AgNP level (P<0.05). Our results revealed that Curcumin supplementation could limit the toxic effects of lower dietary AgNP contents.
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