The overuse of antiparasitic drugs as a method of control has led to insufficient effectiveness and widespread drug resistance worldwide. The aim of this study was to investigate the efficacy of albendazole and levamisole as antiparasitic agents in a lungworm control program in goat flocks. During 2021 and 2022, a total of 110 goats over the age of 4 months and above were randomly selected from 11 herds in the north-western region of Iran. including Saanen breed, both sexes of the same age. The results indicated that 3.6%, 50.8% and 41.9% were infected to Dictyocaulus filaria, Muellerius capillaris and Protostrongylus rufescens , respectively and generally all the lung parasites in goats of this region were resistant to albendazole and levamisole. Due to clinical importance of D. filaria in goats the molecular analysis of two samples was also done. Sequencing results showed that the identified parasites were 100% similar to the reference sequences registered in the GenBank. The results of this research showed low level of efficacy of these anthelmintics were detected against Dictyocaulus and Muelleries. Generally, the lung parasites in goats of this region are resistant to albendazole and levamisole. P. rufecense respiratory worms showed high resistance to these drugs. Totally, it can be concluded that the level of drug resistance varies in different parts of the world, but the frequencies of drug resistance in different parts of the world are not the same and requires more studies.