Document Type : Original Article

Author

Department of Animal Health and Welfare, College of Health and Biotechnology, Semyung University

Abstract

Acute pancreatitis (AP) can develop into life-threatening conditions such as systemic inflammatory response syndrome (SIRS) or multiple organ dysfunction syndrome. Thirty-nine of 54 client-owned dogs admitted to the Referral Animal Medical Center and diagnosed with acute pancreatitis within 24 h of onset were retrospectively reviewed to assess early predictors of progression from AP to SIRS.
The patients were divided into SIRS (SIRS occurring after AP) and non-SIRS (AP occurring but no SIRS) groups. The population and mean values of laboratory variables within 24 h of admission were assessed and compared between both groups. There were significantly more dogs with abnormal lactate levels in the SIRS (80.0%) group than in the non-SIRS group (11.1%). Other parameters did not differ significantly. Mean lactate level values were significantly higher at 3.64 (±1.75) mmol in the SIRS group compared to 1.68 (±0.52) mmol in the non-SIRS group (p=0.003).
The increased energy required by activated immune cells may lead to metabolic changes characterized by anaerobic glycolysis and increased lactate production. This study’s results suggest blood lactate monitoring in the early stages of progression from AP to SIRS in small animal clinical practice. Measuring lactate levels at the early stages of pancreatitis could lead to rapid therapeutic intervention for SIRS and ultimately reduce mortality.

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