Veterinary Research Forum
Vet Res Forum

Protective effect of nanocurcumin on acetaminophen-induced hepatic and renal toxicities in pigeons

Document Type : Original Article

Authors

Saeed Seifi 1
Nasser Vajdi 1
Shohreh Alian Samakkhah 2
Navideh Mirzakhani 3

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran

2 Department of Food Hygiene, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran

3 Department of Pathobiology, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran

https://doi.org/10.30466/vrf.2024.2011585.4009
Abstract
In this study, the effects of nanocurcumin on acetaminophen-induced acute hepatorenal toxicity in domestic pigeons (Columba livia) were investigated. Fifteen pigeons were randomly assigned into three groups. Group I was served as a negative control group and received tap water as a placebo. Pigeons in groups II and III were administered acetaminophen at the beginning of the experiment (hr 0). Group III was further treated with nanocurcumin, at 12 hr after acetaminophen administration, being continued every 12 hr for two days. The birds were observed for clinical signs of acute drug toxicity. Blood samples were collected from the pigeons at hr 0, 12, 24 and 48 of the experiment for biochemical analysis of the serum. The results showed that acetaminophen toxicity increased the serum levels of aspartate aminotransferase, alanine aminotransferase, urea and uric acid in the pigeons. Nanocurcumin treatment of acetaminophen intoxicated pigeons attenuated increases in biomarkers of the liver and kidney functions towards control levels. Also, the consumption of nanocurcumin minimized histopathological changes in the liver and kidney. A mortality of 60.00% was seen in the acetaminophen-induced toxicity group; while, none of the birds treated with nanocurcumin died. It can be concluded that nanocurcumin alleviates the acetaminophen-induced acute toxic liver and kidney damages, which can lead to pigeon mortality.

Keywords

Acetaminophen
Serum biochemistry
Nanocurcumin
Domestic pigeon

Subjects

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Veterinary Research Forum
Volume 15, Issue 3
March 2024
Pages 145-150

  • Receive Date 14 September 2023
  • Revise Date 06 December 2023
  • Accept Date 08 January 2024

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