Veterinary Research Forum
Vet Res Forum

Tonsillar squamous cell carcinoma in a male Lhasa Apso

Document Type : Clinical Report

Authors

Alaleh Rakhshanpour 1
Sayyed Jafar Hasani 2
Ali-Asghar Tehrani 3
Mehdi Behfar 4

1 Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

2 DVM Graduate, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

3 Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

4 Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

https://doi.org/10.30466/vrf.2024.2017462.4096
Abstract
Squamous cell carcinoma (SCC) and more specifically tonsillar SCC are generally regarded as locally invasive with various rates of metastasis. A 13-year-old male Lhasa Apso was referred to the clinic with an unusual mass on his left tonsil and abnormal lumps under the tongue. The dog's food and water intake, breathing and heart rates, body temperature, capillary refill time, and blood tests were normal. A biopsy of abnormal tissue and immunohistochemical analysis were performed. Histopathological and immunohistochemical evaluations confirmed the basaloid SCC. Some treatments like surgery, radiotherapy, and chemotherapy are used to treat a specific tumor or area of the body. However, in this particular case, chemotherapy was not administered. Considering that dogs with tonsillar cancer generally have a poor to guarded prognosis and a short life expectancy, this case was euthanized after one year with the owner's consent due to the significant tumor enlargement.

Keywords

Dog
Immunohistochemistry
Squamous cell carcinoma
Tonsil
Subjects
  1. Mas A, Blackwood L, Cripps P, et al. Canine tonsillar squamous cell carcinoma -- a multi-centre retrospective review of 44 clinical cases. J Small Anim Pract 2011; 52(7): 359-364.
  2. Belluco S, Brisebard E, Watrelot D, et al. Digital squamous cell carcinoma in dogs: epidemiological, histological, and imunohistochemical study. Vet Pathol 2013; 50(6): 1078-1082.
  3. Esplin DG, Wilson SR, Hullinger GA. Squamous cell carcinoma of the anal sac in five dogs. Vet Pathol 2003; 40(3): 332-334.
  4. Palaniappan V, Karthikeyan K. Bowen's Disease. Indian Dermatol Online J 2022; 13(2): 177-189.
  5. Josiah AJ, Twilley D, Pillai SK, et al. Pathogenesis of keratinocyte carcinomas and the therapeutic potential of medicinal plants and phytochemicals. Molecules 2021; 26(7): 1979. doi: 10.3390/molecules26071979.
  6. Didona D, Paolino G, Bottoni U, et al. Non melanoma skin cancer pathogenesis overview. Biomedicines 2018; 6(1): 6. doi: 10.3390/biomedicines6010006
  7. Pogorzelska-Dyrbus J, Szepietowski JC. Adhesion molecules in non-melanoma skin cancers: a com-prehensive review. In Vivo 2021; 35(3): 1327-1336.
  8. Goldschmidt M, Hendrick MJ. Tumors of the skin and soft tissues. In: Meuten DJ (Ed). Tumors in domestic animals. 4th Ames, USA: Iowa State Press 2002:45-117.
  9. Grant J, North S. Evaluation of the factors contributing to long-term survival in canine tonsillar squamous cell carcinoma. Aust Vet J 2016; 94(6): 197-202.
  10. Mickelson MA, Regan D, Randall EK, et al. Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms. Vet Comp Oncol 2020; 18(4): 770-777.
  11. Murphy S, Hayes A, Adams V, et al. Role of carboplatin in multi-modality treatment of canine tonsillar squamous cell carcinoma--a case series of five dogs. J Small Anim Pract 2006; 47(4): 216-220.
Veterinary Research Forum
Volume 15, Issue 7
July 2024
Pages 387-389

  • Receive Date 08 December 2023
  • Revise Date 22 February 2024
  • Accept Date 04 March 2024

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