Veterinary Research Forum
Vet Res Forum

Utilization of mannan oligosaccharides as antibiotic substitutes in laying hens

Document Type : Original Article

Authors

Rosa Angélica Sanmiguel Plazas 1
Olga Teresa Barreto-Cruz 1
Juan Antonio Javierre 2
Diana Camila Mogollon Vergara 1
María Leandra León Miranda 1
Moris Andres Sosa Vargas 1
Erica Liseth Carvajal Peña 1

1 Department of Animal Production, Faculty of Veterinary Medicine and Animal Science, Universidad Cooperativa de Colombia, Ibague, Colombia

2 Department of Research (Innovation and Development), Tekzol SAS, Bogota, Colombia

https://doi.org/10.30466/vrf.2024.2024105.4229
Abstract
Among global concerns about antibiotic resistance, it is necessary to identify food-safe alternatives to enhance production. This study aimed to evaluate the impact of mannan oligosaccharides (MOS) inclusion to replace antibiotic growth promoters (AGP) in the diets of ISA Brown laying hens aged between 23 and 31 weeks. Two hundred forty hens were grouped into five treatments: Control, AGP (130 ppm of enramycin 8.00%), and 100, 200, and 400 ppm of MOS. Each treatment had 16 experimental units (each unit with n = 3) in a randomized block experimental design. Productive data (egg production %, feed intake, egg weight), egg quality variables (albumin height, yolk weight, albumin, yolk %, weight eggshell, eggshell %, equator thickness, width-pole thickness, and Haugh units), organ weights (ovary, liver, and cecum) and jejunal histomorphometry were analyzed. The egg production was not affected by the substitution of AGP by MOS. Furthermore, MOS supplementation resulted in significantly increased feed intake, larger egg weight, higher yolk weight and higher body and ovarium weight compared to the AGP group. Besides, MOS supplementation at 400 ppm demonstrated significant improvements in jejunal villus morphology indicating enhanced intestinal health. These findings highlighted the potential of MOS as an alternative to AGP, offering benefits such as improved feed intake, egg quality and intestinal health in laying hens at 400 ppm.

Keywords

Egg quality
Intestinal health
Performance
Prebiotics
Resistance

Subjects

  1. Jha R, Fouhse JM, Tiwari UP, et al. Dietary fiber and intestinal health of monogastric animals. Front Vet Sci 2019; 6: 48. doi: 10.3389/fvets.2019.00048.
  2. Castanon History of the use of antibiotic as growth promoters in European poultry feeds. Poult Sci 2007; 86(11): 2466-2471.
  3. Adedokun SA, Olojede OC. Optimizing gastrointestinal integrity in poultry: the role of nutrients and feed additives. Front Vet Sci 2019; 5: 348. doi: 10.3389/fvets.2018.00348.
  4. Hao H, Cheng G, Iqbal Z, et al. Benefits and risks of antimicrobial use in food-producing animals. Front Microbiol 2014; 5: 288. doi: 10.3389/fmicb. 2014.00288.
  5. Muhammad J, Khan S, Su JQ, et al. Antibiotics in poultry manure and their associated health issues: a systematic review. J Soils Sediments 2020; 20: 486-497.
  6. Sharma C, Rokana N, Chandra M, et al. Antimicrobial resistance: its surveillance, impact, and alternative management strategies in dairy animals. Front Vet Sci 2018; 4: 237. doi: 10.3389/fvets.2017.00237.
  7. Grenni P, Ancona V, Barra Caracciolo A. Ecological effects of antibiotics on natural ecosystems: a review. Microchem J 2018; 136: 25-39.
  8. François B, Jafri HS, Bonten M. Alternatives to anti-biotics. Intensive Care Med 2016; 42(12): 2034-2036.
  9. Donoghue DJ. Antibiotic residues in poultry tissues and eggs: human health concerns? Poult Sci 2003; 82(4): 618-621.
  10. Tang KL, Caffrey NP, Nóbrega DB, et al. Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis. Lancet Planet Health 2017; 1(8): e316-e327.
  11. Alagawany M, Farag MR, Salah AS, et al. The role of oregano herb and its derivatives as immunomodulators in fish. Rev Aquac 2020; 12(4): 2481-2492.
  12. Newman AM, Arshad M. The role of probiotics, prebiotics and synbiotics in combating multidrug-resistant organisms. Clin Ther 2020; 42(9): 1637-1648.
  13. Barreto-Cruz OT, Henao Zambrano JC, Castañeda-Serrano RD, et al. Assessing the in vitro and in vivo effect of supplementation with a garlic (Allium sativum) and oregano (Origanum vulgare) essential oil mixture on digestibility in West African sheep. Vet Sci 2023; 10(12): 695. doi: 10.3390/vetsci10120695.
  14. Markowiak P, Śliżewska K. The role of probiotics, prebiotics and synbiotics in animal nutrition. Gut Pathog 2018; 10: 21. doi: 10.1186/s13099-018-0250-0.
  15. Fernandez-Alarcon MF, Trottier N, Steibel JP, et al. Interference of age and supplementation of direct-fed microbial and essential oil in the activity of digestive enzymes and expression of genes related to transport and digestion of carbohydrates and proteins in the small intestine of broilers. Poult Sci 2017; 96(8): 2920-2930.
  16. Anadón A, Ares I, Martínez-Larrañaga MR, et al. Enzymes in feed and animal health. In: Gupta R, Srivastava A, Lall R. (Eds) Nutraceuticals in veterinary medicine. Cham, Switzerland: Springer Cham 2019; 303-313.
  17. Youssef IM, Khalil HA, Jaber FA, et al. Influence of dietary mannan-oligosaccharides supplementation on hematological characteristics, blood biochemical parameters, immune response and histological state of laying hens. Poult Sci 2023; 102(11): 103071. doi: 10.1016/j.psj.2023.103071.
  18. White LA, Newman MC, Cromwell GL, et al. Brewers dried yeast as a source of mannan oligosaccharides for weanling pigs. J Anim Sci 2002; 80(10): 2619-2628.
  19. Pourabedin M, Xu Z, Baurhoo B, et al. Effects of mannan oligosaccharide and virginiamycin on the cecal microbial community and intestinal morphology of chickens raised under suboptimal conditions. Can J Microbiol 2014; 60(5): 255-266.
  20. Yalçinkaya I, Güngör T, Başalan M, et al. Mannan oligosaccharides (MOS) from Saccharomyces cerevisiae in broilers: effects on performance and blood biochemistry. Turkish J Vet Anim Sci 2008; 32(1): 43-48.
  21. Kumar Suryawanshi R, Kango N. Production of mannooligosaccharides from various mannans and evaluation of their prebiotic potential. Food Chem 2021; 334: 127428. doi: 10.1016/j.foodchem. 2020.127428.
  22. Chacher MFA, Kamran Z, Ahsan U, et al. Use of mannan oligosaccharide in broiler diets: an overview of underlying mechanisms. Worlds Poult Sci J 2017; 73(4): 831-844.
  23. Hoving LR, van der Zande HJP, Pronk A, et al. Dietary yeast-derived mannan oligosaccharides have immune-modulatory properties but do not improve high fat diet-induced obesity and glucose intolerance. PLoS One 2018; 13(5): e0196165. doi: 10.1371/journal. pone.0196165.
  24. Pandey AK, Kumar P, Saxena MJ. Feed additives in animal health. In: Gupta R, Srivastava A, Lall R. (Eds) Nutraceuticals in veterinary medicine. Cham, Switzerland: Springer Cham 2019; 345-362.
  25. Merrifield DL, Ringø E. Aquaculture nutrition: gut health, probiotics and prebiotics. Hoboken, USA: John Wiley & Sons 2014; 185-222.
  26. Asadpoor M, Ithakisiou GN, Henricks PAJ, et al. Non-digestible oligosaccharides and short chain fatty acids as therapeutic targets against enterotoxin-producing bacteria and their toxins. Toxins (Basel) 2021; 13(3): 175. doi: 10.3390/toxins13030175.
  27. Saeed M, Ahmad F, Arain MA, et al. Use of mannan- oligosaccharides (MOS) as a feed additive in poultry nutrition. J World Poult Res 2017; 7(3): 94-103.
  28. Ghasemian M, Jahanian R. Dietary mannan-oligosaccharides supplementation could affect performance, immunocompetence, serum lipid metabolites, intestinal bacterial populations, and ileal nutrient digestibility in aged laying hens. Anim Feed Sci Technol 2016; 213: 81-89.
  29. Zheng J, Li H, Zhang X, et al. Prebiotic mannan-oligosaccharides augment the hypoglycemic effects of metformin in correlation with modulating gut microbiota. J Agric Food Chem 2018; 66(23): 5821-5831.
  30. NRC National research council. Nutrient Requirements of Poultry. 9th NRC National research council. Washington DC, USA: National Academies Press; 1994.
  31. Jahanian R, Ashnagar M. Effect of dietary supplementation of mannan-oligosaccharides on performance, blood metabolites, ileal nutrient digestibility, and gut microflora in Escherichia coli-challenged laying hens. Poult Sci 2015;94(9): 2165-2172.
  32. Silversides FG, Villeneuve P. Is the Haugh unit correction for egg weight valid for eggs stored at room temperature? Poult Sci 1994; 73(1): 50-55.
  33. Mota-Rojas D, Maldonado MJ, Becerril MH, et al. Welfare at slaughter of broiler chickens: a review. Int J Poult Sci 2008; 7(1): 1-5.
  34. Suvarna KS, Layton C, Bancroft JD. Bancroft’s theory and practice of histological techniques. 8th London, UK: Elsevier 2018; 40-63 .
  35. IBM SPSS Statistics for Windows. Armonk, NY: IBM Corp.; 2019.
  36. Bozkurt M, Bintaş E, Kırkan Ş, et al. Comparative evaluation of dietary supplementation with mannan oligosaccharide and oregano essential oil in forced molted and fully fed laying hens between 82 and 106 weeks of age. Poult Sci 2016; 95(11): 2576-2591.
  37. Iqbal MA, Roohi N, Akram M, et al. Egg quality and egg geometry influenced by mannan-oligosaccharides (MOS), a prebiotic supplementation in four closebred flocks of Japanese quail breeders (Coturnix coturnix japonica). Pakistan J Zool 2015; 47(3): 641-648.
  38. Shalaei M, Hosseini SM, Zergani E. Effect of different supplements on eggshell quality, some characteristics of gastrointestinal tract and performance of laying hens. Vet Res Forum 2014; 5(4): 277-286.
  39. Shashidhara RG, Devegowda G. Effect of dietary mannan oligosaccharide on broiler breeder production traits and immunity. Poult Sci 2003; 82(8): 1319-1325.
  40. Hassanein SM, Soliman NK. Effect of probiotic (Saccharomyces cerevisae) adding to diets on intestinal microflora and performance of Hy-Line layer hens. J Am Sci 2010; 6(11): 159-169.
  41. Biasato I, Ferrocino I, Biasibetti E, et al. Modulation of intestinal microbiota, morphology and mucin composition by dietary insect meal inclusion in free-range chickens. BMC Vet Res 2018; 14(1): 383. doi: 10.1186/s12917-018-1690-y.
  42. Aristimunha PC, Mallheiros RD, Ferket PR, et al. Effect of dietary organic acids and humic substance supplementation on performance, immune response and gut morphology of broiler chickens. J Appl Poult Res 2020; 29(1): 85-94.
  43. Baurhoo B, Phillip L, Ruiz-Feria CA. Effects of purified lignin and mannan oligosaccharides on intestinal integrity and microbial populations in the ceca and litter of broiler chickens. Poult Sci 2007; 86(6): 1070-1078.
  44. Hajiaghapour M, Rezaeipour V. Comparison of two herbal essential oils, probiotic, and mannan-oligosaccharides on egg production, hatchability, serum metabolites, intestinal morphology, and microbiota activity of quail breeders. Livest Sci 2018; 210: 93-98.
  45. Hazrati S, Rezaeipour V, Asadzadeh S. Effects of phytogenic feed additives, probiotic and mannan-oligosaccharides on performance, blood metabolites, meat quality, intestinal morphology, and microbial population of Japanese quail. Br Poult Sci 2020; 61(2): 132-139.
  46. Brenes A, Roura E. Essential oils in poultry nutrition: main effects and modes of action. Anim Feed Sci Technol 2010; 158(1-2): 1-14.
Veterinary Research Forum
Volume 15, Issue 12
December 2024
Pages 645-650

  • Receive Date 23 April 2024
  • Revise Date 03 August 2024
  • Accept Date 11 September 2024

Home

Guide for Authors

Submit Manuscript

Reviewers

Contact Us