Veterinary Research Forum
Vet Res Forum

Determination of the effect of Tarantula cubensis alcoholic extract on cadmium embryotoxicity

Document Type : Original Article

Authors

Rahmi Canbar 1
Gokhan Akcakavak 2
Muhittin Uslu 3
Mustafa Sedat Arslan 4
Harun Kizilay 5

1 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Necmettin Erbakan University, Konya, Türkiye

2 Department of Pathology, Faculty of Veterinary Medicine, Aksaray University, Aksaray, Türkiye

3 Department of Laboratory and Veterinary Health, Sefaatli Vocational College, Yozgat Bozok University, Yozgat, Türkiye

4 Prof. Dr. Humeyra Ozgen Research and Application Farm, Faculty of Veterinary Medicine, Selcuk University, Konya, Türkiye

5 Department of Pharmacology, Faculty of Pharmacy, Selcuk University, Konya, Türkiye

https://doi.org/10.30466/vrf.2024.2031444.4313
Abstract
Tarantula cubensis alcoholic extract (TCAE) is a homeopathic product used in the veterinary field. This study aimed to determine the effects of TCAE on cadmium (Cd) toxicity in the embryo. The study used 220 fertile, incubated chicken eggs divided into 11 equal groups on the 7th day of incubation. The groups comprised untreated and physiological saline control groups, a group with TCAE alone, four groups with varying doses of Cd alone and four groups with the same doses of Cd plus TCAE. At the end of the incubation period, the eggs were opened, kidney and liver tissue samples were taken for histopathology and the number of dead and living embryos were recorded. In the prsent study, the median lethal dose of Cd was determined to be 0.029 mg per egg and the median lethal dose of Cd plus TCAE was determined to be 0.020 mg per egg. The histopathological examinations determined that kidney and liver damage were increased when TCAE and Cd were administered together, that was higher than when Cd was given alone. Thus, TCAE, which had no toxic effect on the embryo when used alone, might increase the embryotoxic activity of Cd. However, more detailed studies are needed.

Keywords

Tarantula cubensis alcoholic extract
Cadmium
Embryotoxic
in ovo methods

Subjects

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Veterinary Research Forum
Volume 16, Issue 4
April 2025
Pages 203-208

  • Receive Date 13 June 2024
  • Revise Date 03 July 2024
  • Accept Date 17 July 2024

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