Veterinary Research Forum

Contribution of polycystic kidney disease to the development of chronic renal dysfunction in cats

Document Type : Original Article

Authors

Amirhossein Jamshidi 1
Baharak Akhtardanesh 2
Mehdi Rasekh 1
Dariush Vosough 2
Mohamad Javad Behzadi 1

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran

2 Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran

https://doi.org/10.30466/vrf.2025.2047804.4574
Abstract
Polycystic kidney disease (PKD) is a hereditary disorder characterized by progressive renal cyst formation, leading to compromised kidney function and an increased risk of chronic kidney disease (CKD). This prospective, 18-month longitudinal study evaluated diagnostic and prognostic markers in 12 PKD-affected cats, utilizing ultrasound imaging alongside biochemical analysis. The study documented a 14.00% increase in cyst volume, a 7.00% enlargement in kidney length, and significant elevations in plasma creatinine, phosphorus, and blood urea nitrogen levels, underscoring their correlation with disease progression. Hematological analysis revealed progressive anemia associated with advanced CKD stages, further outlining the systemic impact of PKD. These findings emphasize the progressive nature of CKD in cats with PKD, despite diligent care provided by pet owners and veterinarians. Also, the importance of routine sonographic evaluation along with hematological and biochemical assessments is highlighted in our study to enhance early detection and improve outcomes in feline PKD. Future longitudinal studies with expanded cohorts are essential to validate these findings and refine diagnostic criteria for PKD-associated CKD.

Keywords

Cat
Chronic kidney disease
Polycystic kidney disease
Prognosis
Ultrasound
Subjects
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Veterinary Research Forum
Volume 17, Issue 5
May 2026
Pages 353-359

  • Receive Date 09 December 2024
  • Revise Date 05 July 2025
  • Accept Date 10 December 2025

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