1. Rubenfeld GD, Caldwell E, Peabody E, et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353(16): 1685-1693.
2. Anspach FB. Endotoxin removal by affinity sorbents. J Biochem Biophys Methods 2001; 49(1-3): 665-681.
3. Ogikubo Y, Norimatsu M, Noda K, et al. Evaluation of the bacterial endotoxin test for quantification of endotoxin contamination of porcine vaccines. Biologicals 2004; 32(2): 88-93.
4. Libby P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev 2007; 65(12 Pt 2): S140-S146.
5. Vincent JL, Opal SM, Marshall JC, et al. Sepsis definitions: time for change. Lancet 2013; 381(9868): 774-775.
6. Herken EN, Celik A, Aslan M, et al. The constituents of essential oil: antimicrobial and antioxidant activity of Micromeria congesta Boiss. & Hausskn. ex Boiss. from East Anatolia. J Med Food 2012; 15(9): 835-839.
7. Baytop T. Therapy with medicinal plants in Turkey (past and present). Istanbul, Türkiye: Istanbul University Publication 1984; 337-340.
8. Tropicos. Micromeria congesta Boiss. & Hausskn. Available at: https://www.tropicos.org. Accessed May 25, 2025.
9. Yücel D, Yücel E. Plants used in complementary medicine in the treatment of respiratory tract diseases in Türkiye. Ant J Bot 2022; 6(1): 18-26.
10. Kapucuk FS, Dörtbudak MY, Saytekin AM, et al. Investigation of antibacterial activity of Micromeria congesta and some other plant extracts. Exp Appl Med Sci 2023; 4(3): 541-548.
11. Kapucuk FS, Dinç H. Some aromatic plants used in wound treatment in complementary medicine and their usage methods. Exp Appl Med Sci 2021; 2(4): 257-264.
12. Dinç H, Altun SK. Presence of Escherichia coli in Urfa cheese and in vitro screening of donkey milk and essential oil of Micromeria congesta for antibacterial activity using disc diffusion method. MAE Vet Fak Derg 2017; 2(2): 139-145.
13. Yavuz U, Dinc H, Yigin A, et al. Investigation of the effects of Micromeria congesta essential oil extract on wound healing in rabbits and molecular genetics applications. Indian J Anim Res 2020; 2020: 1289. doi: 10.18805/ijar.B-1289.
14. Dinç H, Yiğin A, Koyuncu İ, et al. Investigation of the anticancer and apoptotic effect of Micromeria congesta under in vitro conditions and detection of related genes by real-time PCR. Vet Res Forum 2022; 13(1): 7-14.
15. Yin Q, Hou S, Yin H, et al. The analgesic and anti-inflammatory effects of zukamu granules, a traditional Chinese medical formulation. Pharm Biol 2019; 57(1): 729-735.
16. National Research Council. Guide for the care and use of laboratory animals. 8th ed. Washington, DC, USA: National Academies Press 2011.
17. Shen W, Gan J, Xu S, et al. Penehyclidine hydrochloride attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway. Pharmacol Res 2009; 60(4): 296-302.
18. Er A, Yazar E. Effects of macrolide antibiotics on blood inflammatory mediators and organ damage markers in lipopolysaccharide-induced pulmonary damage rats [Turkish]. Eurasian J Vet Sci 2010; 26(1): 7-13.
19. Abu-Gharbieh E, Shehab NG, Khan SA. Anti-inflammatory and gastroprotective activities of the aqueous extract of Micromeria fruticosa (L.) Druce ssp Serpyllifolia in mice. Pak J Pharm Sci 2013; 26(4): 799-803.
20. Vladimir-Knežević S, Cvijanović O, Blažeković B, et al. Hepatoprotective effects of Micromeria croatica ethanolic extract against CCl4-induced liver injury in mice. BMC Complement Altern Med 2015; 15: 233. doi: 10.1186/s12906-015-0763-8.
21. Yilmaz E, Cadirci E. Investigation of the effects of sphingosine-1-phosphate receptor agonist fingolimod on Jak2/Stat3 proteins in LPS-induced sepsis-related lung injury [Turkish]. Master’s Thesis. Atatürk University, Erzurum, Türkiye: 2022.
22. Håkansson HF, Smailagic A, Brunmark C, et al. Altered lung function relates to inflammation in an acute LPS mouse model. Pulm Pharmacol Ther 2012; 25(5): 399-406.
23. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 2004; 37(4): 277-285.
24. Dörtbudak MB, Sağlam YS, Yıldırım S, et al. Examination of adenoviruses with molecular and pathological methods in sheep pneumonia cases [Spanish]. Revista MVZ Córdoba. 2022; 27 (Supl): e2738. doi: 10.21897/rmvz.2738.
25. Jamovi. Jamovi (version 2.5). Sydney, Australia: The Jamovi project. Available at: https://www.jamovi.org. Accessed July 15, 2025.
26. Karpurapu M, Lee YG, Qian Z, et al. Inhibition of nuclear factor of activated T cells (NFAT) c3 activation attenuates acute lung injury and pulmonary edema in murine models of sepsis. Oncotarget 2018; 9(12): 10606-10620.
27. Domscheit H, Hegeman MA, Carvalho N, et al. Molecular dynamics of lipopolysaccharide-induced lung injury in rodents. Front Physiol 2020; 11: 36. doi: 10.3389/fphys.2020.00036.
28. Fodor RŞ, Georgescu AM, Cioc AD, et al. Time- and dose-dependent severity of lung injury in a rat model of sepsis. Rom J Morphol Embryol. 2015; 56(4): 1329-1337.
29. Shi D, Zheng M, Wang Y, et al. Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice. Pharm Biol 2014; 52(6): 729-734.
30. Gül F, Arslantaş MK, Cinel İ, et al. Changing definitions of sepsis. Turk J Anaesthesiol Reanim 2017; 45(3): 129-138.
31. Akbari B, Baghaei-Yazdi N, Bahmaie M, et al. The role of plant-derived natural antioxidants in reduction of oxidative stress. BioFactors 2022; 48(3): 611-633.
32. Kar E, Alataş Ö, Şahıntürk V, et al. Effects of metformin on lipopolysaccharide induced inflammation by activating fibroblast growth factor 21. Biotechnic Histochem 2022; 97(1): 44-52.
33. Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids- -new mechanisms for old drugs. N Engl J Med 2005; 353(16): 1711-1723.
34. Cain DW, Cidlowski JA. Immune regulation by glucocorticoids. Nat Rev Immunol 2017; 17(4): 233-247.
35. Tanaka H, Nishikawa Y, Fukushima T, et al. Lipopolysaccharide inhibits hepatic gluconeogenesis in rats: the role of immune cells. J Diabetes Investig 2017; 9(3): 494-504.
36. Prince PD, Fischerman L, Toblli JE, et al. LPS-induced renal inflammation is prevented by (−)-epicatechin in rats. Redox Biol 2017; 11: 342-349.
37. Bakirel T, Bakirel U, Keleş OU, et al. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol 2008; 116(1): 64-73.
38. Nabil-Adam A, Ashour ML, Shreadah MA. Modulation of MAPK/NF-κB pathway and NLRP3 inflammasome by secondary metabolites from red algae: a mechanistic study. ACS Omega 2023; 8(41): 37971-37990.
39. Chen J, Wang S, Fu R, et al. RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice. J Transl Med 2018; 16(1): 233. doi: 10.1186/s12967-018-1606-4.
40. Jiang L, Zhang L, Kang K, et al. Resveratrol ameliorates LPS-induced acute lung injury via NLRP3 inflammasome modulation. Biomed Pharmacother 2016; 84: 130-138.
41. Zhou R, Yazdi AS, Menu P, et al. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469(7329): 221-225.
42. Hoogland IC, Houbolt C, van Westerloo DJ, et al. Systemic inflammation and microglial activation: systematic review of animal experiments. J Neuro-inflammation 2015; 12: 114. doi: 10.1186/s12974-015-0332-6.
43. Huang X, Zeng Y, Jiang Y, et al. Lipopolysaccharide-binding protein downregulates fractalkine through activation of p38 MAPK and NF-κB. Mediators Inflamm 2017; 2017: 9734837. doi: 10.1155/2017/9734837.
44. Yang Q, Luo J, Lv H, et al. Pulegone inhibits inflammation via suppression of NLRP3 inflammasome and reducing cytokine production in mice. Immuno-pharmacol Immunotoxicol 2019; 41(3): 420-427.
45. Yang Q, Liu Q, Lv H, et al. Effect of pulegone on the NLRP3 inflammasome during inflammatory activation of THP-1 cells. Exp Ther Med 2020; 19(2): 1304-1312.
46. Kim SY, Sapkota A, Bae YJ, et al. The anti-atopic dermatitis effects of Mentha arvensis essential oil are involved in the inhibition of the NLRP3 inflammasome in DNCB-challenged atopic dermatitis BALB/c mice. Int J Mol Sci 2023; 24(9): 7720. doi: 10.3390/ ijms24097720.
47. Liao J, Xie X, Wang W, et al. Anti-inflammatory activity of essential oil from leaves of Blumea balsamifera (L.) DC through inhibiting TLR4/NF-kB signaling pathways and NLRP3 inflammasome activation in LPS-induced RAW264.7 macrophage cells. J Essent Oil-Bear Plants 2021; 24(1): 1912645. doi: 10.1080/0972060X. 2021.1912645.
48. Wan M, Yao YF, Wu W, et al. Chimonanthus nitens Oliv. essential oil mitigates lipopolysaccharide-induced acute lung injury in rats. Food Chem Toxicol 2021; 156: 112445. doi: 10.1016/j.fct.2021.112445.
49. Roy A, Park HJ, Abdul QA, et al. Pulegone exhibits anti-inflammatory activities through the regulation of NF-κB and Nrf-2 signaling pathways in LPS-stimulated RAW 264.7 cells. Nat Prod Sci 2018; 24(1): 28-35.