Document Type : Original Article
Authors
1
Department of Food Hygiene and Quality Control, Urmia University, Urmia, Iran.
2
Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
3
Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
10.30466/vrf.2026.2087896.5084
Abstract
The rising demand for natural wound dressings has spotlighted bacterial nanocellulose (BNC), produced by Komagataeibacter xylinus, for its biocompatibility, biodegradability, and high crystallinity. Combined with honey (renowned for antimicrobial, anti-inflammatory, and regenerative properties) this composite offers enhanced therapeutic potential. This study evaluated the efficacy of BNC/honey composites in healing excisional wounds in mice. Twenty-four mice were divided into four groups: untreated control, honey-only, BNC-only, and BNC/honey composite. An 8-mm full-thickness wound was created dorsally, and healing was monitored over 14 days. Planimetry showed accelerated wound contraction in the composite group. Histopathology (days 7 and 14) revealed superior tissue regeneration, increased angiogenesis, and fibroblast proliferation. Biochemical assays demonstrated significantly elevated total antioxidant capacity and glutathione peroxidase activity, alongside reduced oxidative stress markers (TOS, MDA) in the composite group. Hydroxyproline levels, indicating collagen synthesis, were also highest in this group. Collectively, the BNC/honey composite markedly enhanced wound healing by promoting collagen deposition, reducing inflammation, and boosting antioxidant defense. These findings position the BNC/honey composite as a highly promising, natural biomaterial for advanced wound care with strong translational potential in clinical settings.
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