Volume 15 (2024)
Volume 14 (2023)
Volume 13 (2022)
Volume 12 (2021)
Volume 11 (2020)
Volume 10 (2019)
Volume 9 (2018)
Volume 8 (2017)
Volume 7 (2016)
Volume 6 (2015)
Volume 5 (2014)
Volume 4 (2013)
Volume 3 (2012)
Volume 2 (2011)
Volume 1 (2010)
Effect of crocin on experimental gastrocnemius muscle ischemia/reperfusion injury in rat

Betul Apaydin Yildirim; Selcuk Albayrak

Volume 14, Issue 4 , April 2023, , Pages 201-206

  Ischemia-reperfusion (IR) injury to the lower extremities causes damage to various tissues, notably the limbs. Because research in recent years have demonstrated that saffron and its components are useful in ischemic strokes, the goal of this study was to see whether Crocin (Cr), one of the active constituents ...  Read More

Possible protective effects of crocin on destructive side effects of cyclo-phosphamide in mice ovarian tissue: Evaluation of histomorphometrical and biochemical changes

Fahimeh Khanmohammadi; Rasoul Shahrooz; Abbas Ahmadi; Mazdak Razi

Volume 12, Issue 2 , June 2021, , Pages 217-222

  One of the side effects of cyclophosphamide (CP) is low fertility. In this study, we investigated the protective role of crocin (Cr) against CP chemotherapy-induced changes in ovarian tissue. In the current study, we treated 15 female mice aged 6-8 weeks old for 21 days. The mice were distributed into ...  Read More

Crocin exerts improving effects on indomethacin-induced small intestinal ulcer by antioxidant, anti-inflammatory and anti-apoptotic mechanisms

Sadat Ghafarzadeh; Rahim Hobbenaghi; Esmaeal Tamaddonfard; Amir Abbas Farshid; Mehdi Imani

Volume 10, Issue 4 , December 2019, , Pages 277-284

  Crocin is a plant-derived carotenoid and bears potent antioxidant property. Ranitidine (a histamine H2 receptor blocker) is used for peptic ulcer treatment. The present study was planned to investigate the effects of crocin and ranitidine on indomethacin-induced ulcer in small intestine of rats. Animals ...  Read More

The effects of crocin, mesalazine and their combination in the acetic acid-induced colitis in rats

Amir Faramarzpour; Ali Asghar Tehrani; Esmaeal Tamaddonfard; Mehdi Imani

Volume 10, Issue 3 , September 2019, , Pages 227-234

  Crocin, as a carotenoid compound of saffron, exerts a potent antioxidant property. Mesalazine is frequently used in the treatment of ulcerative colitis. This study investigated the effects of separated and combination treatments with crocin and mesalazine in a rat model of ulcerative colitis. Ulcerative ...  Read More

Evaluation of antioxidant effects of crocin on sperm quality in cyclophosphamide treated adult mice

Zahra Bakhtiary; Rasoul Shahrooz; Abbas Ahmadi; Leila Zarei

Volume 5, Issue 3 , July 2014, , Pages 213-218

  Cyclophosphamide (CP) is one of the anti-neoplastic drugs. Despite its numerous clinical applications, it has devastating effects on the testicles and declines the sperm quality in treated patients. This study was aimed to investigate the protective effect of crocin in improving the toxicity induced ...  Read More