Pathology
Emin Karakurt; Nuvit Coskun; Uğur Aydın; Serpil Dağ; Enver Beytut; Veysel Soydal Ataseven; Volkan Yılmaz; Fırat Doğan; Hilmi Nuhoğlu; Celal Şahin Ermutlu; Ayfer Yıldız
Articles in Press, Accepted Manuscript, Available Online from 02 December 2023
Abstract
This study was aimed at the evaluation of cell proliferation, the p53 tumor-suppressor gene and the apoptosis index by immunohistochemical methods in canine oral papillomatosis. The study material comprised of tumor tissue samples taken from six dogs, which were admitted to the Pathology Department. ...
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This study was aimed at the evaluation of cell proliferation, the p53 tumor-suppressor gene and the apoptosis index by immunohistochemical methods in canine oral papillomatosis. The study material comprised of tumor tissue samples taken from six dogs, which were admitted to the Pathology Department. Choice of immunohistochemical staining was avidin-biotin peroxidase method. Cases of canine oral papillomatosis, determined to have been caused by CPV-1, were found to have a rather high cell proliferation index, Proliferating Cell Nucleus Antigen (PCNA). Furthermore, all cases were immunohistochemically demonstrated to carry a mutant p53 gene. Despite the mutation of the p53 gene, the shift in the Bax/Bcl-2 ratio of the dogs diagnosed with tumor was in favor of the proapoptotic Bax gene. The apoptotic mechanism was determined to occur through both the caspase-dependent and caspase-independent pathways. While the lesions occupied the entire oral cavity in some cases, histopathologically, malignant transformation was not detected in any of the 6 cases.
Annahita Rezaie; Abbas Tavassoli
Volume 3, Issue 2 , June 2012, , Pages 147-149
Abstract
An 11 year – old mixed female Labrador was presented with two masses in trunk and neck. The tumoral masses were excised and sent for histopathological and immunohistochemical analyses. Histopathological examination of masses revealed diffuse infiltration of small sized lymphoid cells in subcutaneous ...
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An 11 year – old mixed female Labrador was presented with two masses in trunk and neck. The tumoral masses were excised and sent for histopathological and immunohistochemical analyses. Histopathological examination of masses revealed diffuse infiltration of small sized lymphoid cells in subcutaneous tissue which were intense around the blood vessels. More than 10% lymphoid cells were CD3 positive in the immunohistochemical staining and most of them were accumulated around vessels. Protein 53 (p53) expression was detected by brown nuclei in immunohistochemical staining. Subcutaneous lymphoma was diagnosed according to histopathological results. After 6 months the case was referred with multicentric lymphoma and based on the owner request euthanasia was performed. These findings emphasize on poor prognosis for tumors with p53 mutation.
