Surgery
Hossein Kazemi Mehrjerdi; Amir Moghaddam Jafari; Bahareh Hafezi
Articles in Press, Accepted Manuscript, Available Online from 18 May 2024
Abstract
This study investigated the effect of captopril on spinal cord ischemia-reperfusion injury in rats. Twenty-four adult male Wistar rats were randomly divided into 4 groups (n= 6 in each group): spinal cord ischemia-reperfusion with captopril (SCI-R+Cap), spinal cord ischemia-reperfusion (SCI-R), sham-operated ...
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This study investigated the effect of captopril on spinal cord ischemia-reperfusion injury in rats. Twenty-four adult male Wistar rats were randomly divided into 4 groups (n= 6 in each group): spinal cord ischemia-reperfusion with captopril (SCI-R+Cap), spinal cord ischemia-reperfusion (SCI-R), sham-operated with captopril (SHAM+Cap), and SHAM. Captopril was administered intragastrically (100.00 mg kg-1) to the SHAM+Cap, and SCI-R+Cap groups, 24, and 1.5 hours before ischemia induction. Abdominal aortic clamping was performed in the SCI-R, and SCI-R+Cap groups for 40 minutes. Hindlimb motor function was evaluated using the Tarlov Scale at 4, 6, 12, 24, 48, and 60 hours after SCII. The malondialdehyde (MDA), ferric reducing ability of plasma (FRAP), and Prooxidant–Antioxidant balance (PAB) values were also measured. Throughout the study period, the SCI-R group had significantly lower motor function scores than the other groups (P < 0.05). The MDA, and PAB levels were higher, and FRAP value was lower in the SCI-R group than in the SHAM group (P < 0.05). The SCI-R+Cap had higher motor function scores than the SCI-R group at all time points (P < 0.05). There were no notable differences in MDA concentration, FRAP, and PAB values between the SCI-R+Cap, and SCI-R groups (P> 0.05). Captopril may act as a protective agent against spinal cord ischemia-reperfusion injury in rats based on hind limb motor function assessment.
