Veterinary Research Forum
Vet Res Forum

Effects of nano-manganese on humoral immune response and oxidative stress in broilers

Document Type : Original Article

Authors

Sepideh Sabaghi 1
Jamshid Razmyar 2
Mohammad Heidarpour 2

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

2 Department of Avian Health and Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

https://doi.org/10.30466/vrf.2020.114233.2716
Abstract
The objective of the present study was to evaluate the alterations in selected indicators of immune responses and oxidative stress of broilers fed with nano-manganese. One hundred-sixty 1-day-old broiler chicks were randomly assigned into four groups with three replicates. Birds were fed the same basal diet supplemented with nano-manganese oxide, as 0.00 (control group), 50.00, 100, or 150 mg kg-1 of diet. The birds were vaccinated against avian influenza (AI), Newcastle disease (ND), infectious bronchitis (IB) and infectious bursal disease (IBD) as the standard vaccination schedule. Blood sample was taken from the brachial vein of birds on 42th day. A significant decrease in antibody titer against sheep RBC was revealed in the nano-manganese 100 and 150 groups compared to the control group. In addition, the antibody titers against IB and ND were significantly lower in the all nano-manganese groups compared to the control group. No significant difference was observed for the antibody titer against AI and oxidative stress indices among the experimental groups. The findings in the present study suggested that nano-manganese at 50.00, 100 and 150 mg kg-1 levels might suppress humoral immune response in broilers which should be taken into consideration in supplementation.

Keywords

Broilers
Immune response
Nano-manganese
Oxidative stress
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Veterinary Research Forum
Volume 12, Issue 4
Autumn 2021
Pages 487-491

  • Receive Date 14 September 2019
  • Revise Date 22 January 2020
  • Accept Date 28 March 2020

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