Veterinary Research Forum
Vet Res Forum

Successful treatment of Candida albicans-induced fungal cystitis in a dog using caspofungin: a case report

Document Type : Clinical Report

Author

Sei-Myoung Han

Department of Animal Health and Welfare, College of Health and Biotechnology, Semyung University, Jecheon, South Korea

https://doi.org/10.30466/vrf.2024.2018960.4113
Abstract
A 7-year-old castrated male poodle was brought to the referral Animal Medical Center and diagnosed with diabetes and pancreatitis. One month later, the patient presented with cloudy urine, and ultrasonography revealed a large number of spherical substances. The patient was subsequently diagnosed with fungal cystitis with Candida albicans. Initially, 10.00 mg kg-1 itraconazole was prescribed twice daily for six weeks, and the symptoms of prolonged urination improved; however, the fungal balls persisted in the bladder. The six months later, the patient showed recurrent symptoms, such as dysuria and stranguria; therefore, 5.00 mg kg-1 fluconazole was prescribed twice daily; however, it was not effective. Subsequently, 1.00 mg kg-1 caspofungin once daily was administered for three consecutive days. Finally, the fungal balls in the bladder disappeared. The patient was regularly monitored after completion of treatment and, 17 months later, doing well without recurrence. Few reports exist on the use of caspofungin in veterinary medicine. The recommended dose of caspofungin in dogs remains unknown. In the case of azole-resistant Candida, treatment using caspofungin should be considered; although, additional studies on the established dosing and side effects are needed.

Keywords

Anti-fungal drugs
Azole-resistant candidiasis
Candida albicans
Caspofungin
Fungal cystitis

Subjects

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Veterinary Research Forum
Volume 15, Issue 8
August 2024
Pages 435-438

  • Receive Date 28 December 2023
  • Revise Date 21 March 2024
  • Accept Date 07 May 2024

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