Veterinary Research Forum

Concurrent occurrence of metastatic cutaneous melanoma and early feline diffuse iris melanoma in a cat

Document Type : Clinical Report

Authors

Yesari Eroksuz 1
Sumeyye Babacan 2
Eren Polat 3
Mustafa Issi 2
Necati Timurkaan 1
Burak Karabulut 1
Elif Ekinci 1

1 Department of Pathology, Faculty of Veterinary Medicine, Firat University, Elazig, Türkiye

2 Department of Internal Medicine, Faculty of Veterinary Medicine, Firat University, Elazig, Türkiye

3 Department of Surgery, Faculty of Veterinary Medicine, Firat University, Elazig, Türkiye

https://doi.org/10.30466/vrf.2024.2037225.4385
Abstract
This report presented a case of the concurrent diagnosis of early feline diffuse iris melanoma (FDIM) and metastatic cutaneous melanoma in a tricolored mixed stray cat. Histopathological examination of biopsy samples identified melanoma on the nasal planum, lips along with metastasis to the submandibular lymph nodes. The initial treatment included surgical resection of the primary nasal planum neoplasm and the metastatic lesions in the submandibular lymph nodes. The necropsy, performed 40 days after the surgery, revealed the metastatic nodules in multiple organs including the liver, lungs, thyroids, pericardium, pleura, peritoneum, kidneys, and numerous lymph nodes. Histopathological examination revealed a biphasic neoplastic tissue composed of a mixture of epithelioid and spindle cells in primary and metastatic tumors. Additionally, the anterior surface of the iris contained 4 - 5 rows of melanocytic interstitial infiltration indicative of early FDIM. Immunohistochemical analysis revealed that the neoplastic cells showed positive immunoreactivity for Melan-A. To the authors' knowledge, this case represented the first reported case of concurrent FDIM and cutaneous melanoma in a feline patient.

Keywords

Cat
Cutaneous melanoma
Feline diffuse iris melanoma
Subjects
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Veterinary Research Forum
Volume 16, Issue 8
August 2025
Pages 481-484

  • Receive Date 31 July 2024
  • Revise Date 27 August 2024
  • Accept Date 11 September 2024

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