Volume 15 (2024)
Volume 14 (2023)
Volume 13 (2022)
Volume 12 (2021)
Volume 11 (2020)
Volume 10 (2019)
Volume 9 (2018)
Volume 8 (2017)
Volume 7 (2016)
Volume 6 (2015)
Volume 5 (2014)
Volume 4 (2013)
Volume 3 (2012)
Volume 2 (2011)
Volume 1 (2010)
Computational design of a chimeric toxin against Claudin-4-expressing cancer cells: molecular modeling, docking and molecular dynamics simulation analysis

Sepehr Safaei; Mehdi Imani

Volume 14, Issue 5 , May 2023, , Pages 259-265

  Cancer is one of the main reasons of mortality all over the world. Over the time, the major ways for cancer-therapy were based on radiotherapy, chemotherapy and surgery. These methods are not specific enough for that purpose, therefore, new ideas for design of new drugs with higher specificity are considered. ...  Read More

Cytotoxic effect of sea anemone pore-forming toxin on K562 chronic myeloid leukemia cells

Vali Abdoli; Roya Sarkhosh-Inanlou; Nowruz Delirezh; Safiyeh Aghazadeh; Nima ShaykhBaygloo; Mehdi Imani

Volume 12, Issue 4 , December 2021, , Pages 481-485

  Chronic myelogenous leukemia (CML) is one of prevalent cancer worldwide. In spite of various designed drugs, chemoresistance remains the main obstacle in cancer cure. Therefore, developing novel strategy for treatment of CML is an urgent need. Fragaceatoxin C (FraC) is novel protein toxin from a ...  Read More

Serine proteases activity in miracidia of Fasciola hepatica and effects of ‎chemical and herbal inhibitors

Leila Kianifard; Mohammad Yakhchali; Mehdi Imani

Volume 12, Issue 3 , September 2021, , Pages 291-295

  Fasciolosis is a zoonotic parasitic disease caused by the trematode Fasciola hepatica. The proteases are essential for the survival of parasites. The present study was aimed to determine serine proteases activities in miracidia of F. hepatica and evaluate the effects of pH and different inhibitors on ...  Read More

Effects of intraperitoneal and intracerebroventricular injection of cinnamaldehyde and yohimbine on blood glucose and serum insulin concentrations in ketamine-xylazine induced acute hyperglycemia

Farshad Safaei; Esmaeal Tamaddonfard; Saeed Nafisi; Mehdi Imani

Volume 12, Issue 2 , June 2021, , Pages 149-156

  This study was designed to investigate the effects of peripheral [intraperitoneal (IP)] and central [intracerebroventricular (ICV)] administration of cinnamaldehyde on concentrations of blood glucose and serum insulin in the acute hyperglycemia induced by ketamine/xylazine. Yohimbine (a α2-adrenoceptor ...  Read More

Crocin exerts improving effects on indomethacin-induced small intestinal ulcer by antioxidant, anti-inflammatory and anti-apoptotic mechanisms

Sadat Ghafarzadeh; Rahim Hobbenaghi; Esmaeal Tamaddonfard; Amir Abbas Farshid; Mehdi Imani

Volume 10, Issue 4 , December 2019, , Pages 277-284

  Crocin is a plant-derived carotenoid and bears potent antioxidant property. Ranitidine (a histamine H2 receptor blocker) is used for peptic ulcer treatment. The present study was planned to investigate the effects of crocin and ranitidine on indomethacin-induced ulcer in small intestine of rats. Animals ...  Read More

Evidence of morphine like substance and μ-opioid receptor expression in Toxacara canis (Nematoda: Ascaridae)

Mostafa Golabi; Soraya Naem; Mehdi Imani; Nowruz Dalirezh

Volume 7, Issue 4 , December 2016, , Pages 335-339

  Toxocara canis (Nematoda: Ascaridae) is an intestinal nematode parasite of dogs, which can also cause disease in humans. Transmission to humans usually occurs because of direct contact with T. canis eggs present in soil contaminated with the feces of infected dogs. This nematode has extraordinary abilities ...  Read More