Poultry
Saeed Seifi; Nasser Vajdi; Shohreh Alian Samakkhah; Navideh Mirzakhani
Volume 15, Issue 3 , March 2024, , Pages 145-150
Abstract
In this study, the effects of nanocurcumin on acetaminophen-induced acute hepatorenal toxicity in domestic pigeons (Columba livia) were investigated. Fifteen pigeons were randomly assigned into three groups. Group I was served as a negative control group and received tap water as a placebo. Pigeons in ...
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In this study, the effects of nanocurcumin on acetaminophen-induced acute hepatorenal toxicity in domestic pigeons (Columba livia) were investigated. Fifteen pigeons were randomly assigned into three groups. Group I was served as a negative control group and received tap water as a placebo. Pigeons in groups II and III were administered acetaminophen at the beginning of the experiment (hr 0). Group III was further treated with nanocurcumin, at 12 hr after acetaminophen administration, being continued every 12 hr for two days. The birds were observed for clinical signs of acute drug toxicity. Blood samples were collected from the pigeons at hr 0, 12, 24 and 48 of the experiment for biochemical analysis of the serum. The results showed that acetaminophen toxicity increased the serum levels of aspartate aminotransferase, alanine aminotransferase, urea and uric acid in the pigeons. Nanocurcumin treatment of acetaminophen intoxicated pigeons attenuated increases in biomarkers of the liver and kidney functions towards control levels. Also, the consumption of nanocurcumin minimized histopathological changes in the liver and kidney. A mortality of 60.00% was seen in the acetaminophen-induced toxicity group; while, none of the birds treated with nanocurcumin died. It can be concluded that nanocurcumin alleviates the acetaminophen-induced acute toxic liver and kidney damages, which can lead to pigeon mortality.
Fish & Aquatic
Alireza Afzali-Kordmahalleh; Saeid Meshkini
Volume 14, Issue 11 , November 2023, , Pages 625-630
Abstract
The effects of resveratrol as an anti-oxidant in improving growth and health have been shown in several experiments. This study aimed to evaluate the effects of different dietary resveratrol inclusion levels on digestive enzymes activity and serum biochemistry of rainbow trout (Oncorhynchus mykiss). ...
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The effects of resveratrol as an anti-oxidant in improving growth and health have been shown in several experiments. This study aimed to evaluate the effects of different dietary resveratrol inclusion levels on digestive enzymes activity and serum biochemistry of rainbow trout (Oncorhynchus mykiss). Accordingly, 225 juvenile rainbow trout with an average body weight of 10.00 ± 1.50 g were stocked in nine experimental units. The study was performed as a completely randomized design including three dietary levels of resveratrol as follows: 0.00, 400 and 800 mg kg-1 feed. During the experiment, fish were fed based on their respective body weight using standard feeding tables at three feeding times for 8 weeks. Nine fish were randomly selected from each treatment at the end of the 4th and 8th weeks of the experiment. Results revealed that supplementing 800 mg kg-1 feed resveratrol significantly increased lipase activity (31.40 ± 0.32 U mg-1 protein) compared to the control group (29.92 ± 0.52 U mg-1 protein) at the end of week eight. Also, at the same time, it increased serum high-density lipoprotein (123.04 ± 1.57 mg dL-1) compared to the control group (97.055 ± 1.463 mg dL-1). In addition, dietary supplementation of 800 mg kg-1 feed resveratrol effectively reduced serum alanine aminotransferase, alkaline phosphatase and aspartate aminotransferase activities along with glucose, cortisol and cholesterol. In conclusion, resveratrol can be used as a suitable food supplement to improve fish health by increasing digestive enzymes activities.
